A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice

1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but...

Deskribapen osoa

Xehetasun bibliografikoak
Egile nagusia: Jiří Kassa
Formatua: Artikulua
Hizkuntza:English
Argitaratua: Karolinum Press 1998-01-01
Saila:Acta Medica
Gaiak:
Sarrera elektronikoa:https://actamedica.lfhk.cuni.cz/41/1/0019/
Deskribapena
Gaia:1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but a little less efficacious than other H-oximes (HI- 6, HLö-7). 3. H-oximes (HI-6, HLö-7) seem to be the most efficacious reactivators of nerve agent-inhibited acetylcholinesterase for antidotal treatment of supralethal nerve agent poisoning in mice.
ISSN:1211-4286
1805-9694