A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice
1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but...
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| Format: | Article |
| Language: | English |
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Karolinum Press
1998-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/41/1/0019/ |
| _version_ | 1828191097756581888 |
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| author | Jiří Kassa |
| author_facet | Jiří Kassa |
| author_sort | Jiří Kassa |
| collection | DOAJ |
| description | 1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but a little less efficacious than other H-oximes (HI- 6, HLö-7). 3. H-oximes (HI-6, HLö-7) seem to be the most efficacious reactivators of nerve agent-inhibited acetylcholinesterase for antidotal treatment of supralethal nerve agent poisoning in mice. |
| first_indexed | 2024-04-12T08:33:28Z |
| format | Article |
| id | doaj.art-ec2bc484df0d4ba8889e0089aea8f76c |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-12T08:33:28Z |
| publishDate | 1998-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-ec2bc484df0d4ba8889e0089aea8f76c2022-12-22T03:40:08ZengKarolinum PressActa Medica1211-42861805-96941998-01-01411192110.14712/18059694.2019.162A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in MiceJiří Kassa0Purkyně Military Medical Academy, Hradec Králové, Czech Republic1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but a little less efficacious than other H-oximes (HI- 6, HLö-7). 3. H-oximes (HI-6, HLö-7) seem to be the most efficacious reactivators of nerve agent-inhibited acetylcholinesterase for antidotal treatment of supralethal nerve agent poisoning in mice.https://actamedica.lfhk.cuni.cz/41/1/0019/SomanSarinCyclosinPralidoximeObidoximeMethoxime |
| spellingShingle | Jiří Kassa A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice Acta Medica Soman Sarin Cyclosin Pralidoxime Obidoxime Methoxime |
| title | A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice |
| title_full | A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice |
| title_fullStr | A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice |
| title_full_unstemmed | A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice |
| title_short | A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice |
| title_sort | comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice |
| topic | Soman Sarin Cyclosin Pralidoxime Obidoxime Methoxime |
| url | https://actamedica.lfhk.cuni.cz/41/1/0019/ |
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