Modulation of Fibroblast Phenotype by Colorectal Cancer Cell-Secreted Factors Is Mostly Independent of Oncogenic KRAS

Modulation of Fibroblast Phenotype by Colorectal Cancer Cell-Secreted Factors Is Mostly Independent of Oncogenic KRAS

KRAS mutations have been shown to extend their oncogenic effects beyond the cancer cell, influencing the tumor microenvironment. Herein, we studied the impact of mutant KRAS on the modulation of the pro-tumorigenic properties of cancer-associated fibroblasts (CAFs), including α-SMA expression, TGFβ1...

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Bibliographic Details
Main Authors: Patrícia Dias Carvalho, Susana Mendonça, Flávia Martins, Maria José Oliveira, Sérgia Velho
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
cancer-associated fibroblasts
colorectal cancer
mutant KRAS
secreted factors
Online Access:https://www.mdpi.com/2073-4409/11/16/2490

Internet

https://www.mdpi.com/2073-4409/11/16/2490

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