Assessment of the Human Retinal Neural Selectivity to Square Gratings’ Orientation with the Multifocal and Pattern Electroretinograms
The retinal response to particular orientations might start a signaling cascade of events that help to modulate eye growth and respond to myopia control treatments. The purpose of this study was to investigate the retinal electrical activity in response to grids of different spatial orientations. Th...
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MDPI AG
2023-05-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/10/5/526 |
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| author | Ana Amorim-de-Sousa Paulo Fernandes Noberto López-Gil António Queirós José M. González-Méijome |
| author_facet | Ana Amorim-de-Sousa Paulo Fernandes Noberto López-Gil António Queirós José M. González-Méijome |
| author_sort | Ana Amorim-de-Sousa |
| collection | DOAJ |
| description | The retinal response to particular orientations might start a signaling cascade of events that help to modulate eye growth and respond to myopia control treatments. The purpose of this study was to investigate the retinal electrical activity in response to grids of different spatial orientations. The multifocal (mfERG) and pattern (PERG) ERG responses of nine eyes (spherical equivalent of −0.45 ± 1.15 D; mean age of 32.9 ± 7.7 years) were recorded with four grids (1.2 cpd) oriented at 60°, 90°, 120° and 180° under pupils’ dilation. The mfERG was analyzed by retinal eccentricity, quadrants and meridians with the same orientation of the grids. The response density of mfERG, the amplitudes of PERG and the implicit times of each peak from both tests were analyzed. The grid’s orientation did not evoke different implicit times in both tests. All retinal meridians showed higher response density with grids of parallel orientation to the meridian and lower response density with perpendicularly oriented grids. These differences were statistically significant in the horizontal and 60° meridians (<i>p</i> < 0.050). PERG response did not change with the grids’ orientations. The mfERG was sensitive to detect changes in the outer retinal activity with variations in stimulus orientation. The paradigm of meridional analysis of mfERG results might be more sensitive to orientation changes than the traditional analysis by rings, quadrants or hemifields. |
| first_indexed | 2024-03-11T03:23:55Z |
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| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-11T03:23:55Z |
| publishDate | 2023-05-01 |
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| record_format | Article |
| series | Photonics |
| spelling | doaj.art-ec2cf28d3fc0437793b90775221c519f2023-11-18T02:54:01ZengMDPI AGPhotonics2304-67322023-05-0110552610.3390/photonics10050526Assessment of the Human Retinal Neural Selectivity to Square Gratings’ Orientation with the Multifocal and Pattern ElectroretinogramsAna Amorim-de-Sousa0Paulo Fernandes1Noberto López-Gil2António Queirós3José M. González-Méijome4Clinical and Experimental Optometry Research Laboratory (CEORLab), Physics Center of Minho and Porto Universities (CF-UM-UP), University of Minho, Gualtar, 4710-057 Braga, PortugalClinical and Experimental Optometry Research Laboratory (CEORLab), Physics Center of Minho and Porto Universities (CF-UM-UP), University of Minho, Gualtar, 4710-057 Braga, PortugalFaculty of Optics and Optometry, University of Murcia, Espinardo, 30100 Murcia, SpainClinical and Experimental Optometry Research Laboratory (CEORLab), Physics Center of Minho and Porto Universities (CF-UM-UP), University of Minho, Gualtar, 4710-057 Braga, PortugalClinical and Experimental Optometry Research Laboratory (CEORLab), Physics Center of Minho and Porto Universities (CF-UM-UP), University of Minho, Gualtar, 4710-057 Braga, PortugalThe retinal response to particular orientations might start a signaling cascade of events that help to modulate eye growth and respond to myopia control treatments. The purpose of this study was to investigate the retinal electrical activity in response to grids of different spatial orientations. The multifocal (mfERG) and pattern (PERG) ERG responses of nine eyes (spherical equivalent of −0.45 ± 1.15 D; mean age of 32.9 ± 7.7 years) were recorded with four grids (1.2 cpd) oriented at 60°, 90°, 120° and 180° under pupils’ dilation. The mfERG was analyzed by retinal eccentricity, quadrants and meridians with the same orientation of the grids. The response density of mfERG, the amplitudes of PERG and the implicit times of each peak from both tests were analyzed. The grid’s orientation did not evoke different implicit times in both tests. All retinal meridians showed higher response density with grids of parallel orientation to the meridian and lower response density with perpendicularly oriented grids. These differences were statistically significant in the horizontal and 60° meridians (<i>p</i> < 0.050). PERG response did not change with the grids’ orientations. The mfERG was sensitive to detect changes in the outer retinal activity with variations in stimulus orientation. The paradigm of meridional analysis of mfERG results might be more sensitive to orientation changes than the traditional analysis by rings, quadrants or hemifields.https://www.mdpi.com/2304-6732/10/5/526orientationelectroretinographyretinal activitymeridional effect |
| spellingShingle | Ana Amorim-de-Sousa Paulo Fernandes Noberto López-Gil António Queirós José M. González-Méijome Assessment of the Human Retinal Neural Selectivity to Square Gratings’ Orientation with the Multifocal and Pattern Electroretinograms Photonics orientation electroretinography retinal activity meridional effect |
| title | Assessment of the Human Retinal Neural Selectivity to Square Gratings’ Orientation with the Multifocal and Pattern Electroretinograms |
| title_full | Assessment of the Human Retinal Neural Selectivity to Square Gratings’ Orientation with the Multifocal and Pattern Electroretinograms |
| title_fullStr | Assessment of the Human Retinal Neural Selectivity to Square Gratings’ Orientation with the Multifocal and Pattern Electroretinograms |
| title_full_unstemmed | Assessment of the Human Retinal Neural Selectivity to Square Gratings’ Orientation with the Multifocal and Pattern Electroretinograms |
| title_short | Assessment of the Human Retinal Neural Selectivity to Square Gratings’ Orientation with the Multifocal and Pattern Electroretinograms |
| title_sort | assessment of the human retinal neural selectivity to square gratings orientation with the multifocal and pattern electroretinograms |
| topic | orientation electroretinography retinal activity meridional effect |
| url | https://www.mdpi.com/2304-6732/10/5/526 |
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