Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective
Tissue morphology and mechanics are crucial to the regulation of organ function. Investigating the exceptionally complex tissue of the brain at the sub-micron scale is challenging due to the complex structure and softness of this tissue, despite the large interest of biologists, medical engineers, b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00600/full |
| _version_ | 1819082658674638848 |
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| author | Prem Kumar Viji Babu Manfred Radmacher |
| author_facet | Prem Kumar Viji Babu Manfred Radmacher |
| author_sort | Prem Kumar Viji Babu |
| collection | DOAJ |
| description | Tissue morphology and mechanics are crucial to the regulation of organ function. Investigating the exceptionally complex tissue of the brain at the sub-micron scale is challenging due to the complex structure and softness of this tissue, despite the large interest of biologists, medical engineers, biophysicists, and others in this topic. Atomic force microscopy (AFM) both as an imaging and as a mechanical tool provides an excellent opportunity to study soft biological samples such as live brain tissues. Here we review the principles of AFM, the performance of AFM in tissue imaging and mechanical mapping of cells and tissues, and finally opening the prospects and challenges of probing the biophysical properties of brain tissue using AFM. |
| first_indexed | 2024-12-21T20:20:10Z |
| format | Article |
| id | doaj.art-ec2d2701ee394adf971a287afc14dbc6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-21T20:20:10Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-ec2d2701ee394adf971a287afc14dbc62022-12-21T18:51:30ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-06-011310.3389/fnins.2019.00600453881Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A PerspectivePrem Kumar Viji BabuManfred RadmacherTissue morphology and mechanics are crucial to the regulation of organ function. Investigating the exceptionally complex tissue of the brain at the sub-micron scale is challenging due to the complex structure and softness of this tissue, despite the large interest of biologists, medical engineers, biophysicists, and others in this topic. Atomic force microscopy (AFM) both as an imaging and as a mechanical tool provides an excellent opportunity to study soft biological samples such as live brain tissues. Here we review the principles of AFM, the performance of AFM in tissue imaging and mechanical mapping of cells and tissues, and finally opening the prospects and challenges of probing the biophysical properties of brain tissue using AFM.https://www.frontiersin.org/article/10.3389/fnins.2019.00600/fulltissue morphologytissue mechanicsatomic force microscopy (AFM)tissue imagingmechanical mapping |
| spellingShingle | Prem Kumar Viji Babu Manfred Radmacher Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective Frontiers in Neuroscience tissue morphology tissue mechanics atomic force microscopy (AFM) tissue imaging mechanical mapping |
| title | Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective |
| title_full | Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective |
| title_fullStr | Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective |
| title_full_unstemmed | Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective |
| title_short | Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective |
| title_sort | mechanics of brain tissues studied by atomic force microscopy a perspective |
| topic | tissue morphology tissue mechanics atomic force microscopy (AFM) tissue imaging mechanical mapping |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00600/full |
| work_keys_str_mv | AT premkumarvijibabu mechanicsofbraintissuesstudiedbyatomicforcemicroscopyaperspective AT manfredradmacher mechanicsofbraintissuesstudiedbyatomicforcemicroscopyaperspective |