Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation
Lipid keratopathy (LK) is a rare ophthalmological condition characterized by a progressive reduction in visual acuity caused by corneal opacification due to central lipid accumulation. LK is characterized by lipid deposits, cholesterol clefts, and neovascularization (NV) leading to disruption in cor...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/9/1628 |
| _version_ | 1797602803912278016 |
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| author | Nora Knez Molly Walkenhorst Mohammad Haeri |
| author_facet | Nora Knez Molly Walkenhorst Mohammad Haeri |
| author_sort | Nora Knez |
| collection | DOAJ |
| description | Lipid keratopathy (LK) is a rare ophthalmological condition characterized by a progressive reduction in visual acuity caused by corneal opacification due to central lipid accumulation. LK is characterized by lipid deposits, cholesterol clefts, and neovascularization (NV) leading to disruption in corneal optical quality. LK classification includes a primary and secondary form which depend on pre-existing corneal or systemic disorders and the evidence of NV. Secondary LK is typically associated with a prior occurrence of herpetic infection, such as herpes zoster keratitis. Patients with LK usually present with progressive vision loss and dense cream-colored corneal opacification. Treatment modalities include conservative and surgical approaches focused on corneal NV elimination. When evaluating corneal lipidosis, it is crucial to consider a range of differential diagnoses, including corneal arcus, Schnyder corneal dystrophy, and other corneal deposit conditions. We report a case of a 62-year-old male with herpes zoster keratitis complicated with LK. He presented with painless progressive vision loss and corneal scarring, which raised suspicion about LK diagnosis. This paper emphasizes the importance of correlating clinical and histological findings for accurate LK diagnosis. |
| first_indexed | 2024-03-11T04:21:40Z |
| format | Article |
| id | doaj.art-ec2d74fbae4249aeb8abe89b82679561 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T04:21:40Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-ec2d74fbae4249aeb8abe89b826795612023-11-17T22:46:16ZengMDPI AGDiagnostics2075-44182023-05-01139162810.3390/diagnostics13091628Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical CorrelationNora Knez0Molly Walkenhorst1Mohammad Haeri2Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66103, USADepartment of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66103, USADepartment of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66103, USALipid keratopathy (LK) is a rare ophthalmological condition characterized by a progressive reduction in visual acuity caused by corneal opacification due to central lipid accumulation. LK is characterized by lipid deposits, cholesterol clefts, and neovascularization (NV) leading to disruption in corneal optical quality. LK classification includes a primary and secondary form which depend on pre-existing corneal or systemic disorders and the evidence of NV. Secondary LK is typically associated with a prior occurrence of herpetic infection, such as herpes zoster keratitis. Patients with LK usually present with progressive vision loss and dense cream-colored corneal opacification. Treatment modalities include conservative and surgical approaches focused on corneal NV elimination. When evaluating corneal lipidosis, it is crucial to consider a range of differential diagnoses, including corneal arcus, Schnyder corneal dystrophy, and other corneal deposit conditions. We report a case of a 62-year-old male with herpes zoster keratitis complicated with LK. He presented with painless progressive vision loss and corneal scarring, which raised suspicion about LK diagnosis. This paper emphasizes the importance of correlating clinical and histological findings for accurate LK diagnosis.https://www.mdpi.com/2075-4418/13/9/1628lipid keratopathyherpes zoster keratitiscorneal neovascularisationvision losscorneal arcusSchnyder corneal dystrophy |
| spellingShingle | Nora Knez Molly Walkenhorst Mohammad Haeri Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation Diagnostics lipid keratopathy herpes zoster keratitis corneal neovascularisation vision loss corneal arcus Schnyder corneal dystrophy |
| title | Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation |
| title_full | Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation |
| title_fullStr | Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation |
| title_full_unstemmed | Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation |
| title_short | Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation |
| title_sort | lipid keratopathy histopathology major differential diagnoses and the importance of clinical correlation |
| topic | lipid keratopathy herpes zoster keratitis corneal neovascularisation vision loss corneal arcus Schnyder corneal dystrophy |
| url | https://www.mdpi.com/2075-4418/13/9/1628 |
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