Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis
This study aimed to identify the role of crosslinking agents in the resin–dentin bond strength (BS) when used as modifiers in adhesives or pretreatments to the dentin surface through a systematic review and meta-analysis. This paper was conducted according to the directions of the PRISMA 2020 statem...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Online Access: | https://www.mdpi.com/2073-4409/11/15/2417 |
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| author | Louis Hardan Umer Daood Rim Bourgi Carlos Enrique Cuevas-Suárez Walter Devoto Maciej Zarow Natalia Jakubowicz Juan Eliezer Zamarripa-Calderón Mateusz Radwanski Giovana Orsini Monika Lukomska-Szymanska |
| author_facet | Louis Hardan Umer Daood Rim Bourgi Carlos Enrique Cuevas-Suárez Walter Devoto Maciej Zarow Natalia Jakubowicz Juan Eliezer Zamarripa-Calderón Mateusz Radwanski Giovana Orsini Monika Lukomska-Szymanska |
| author_sort | Louis Hardan |
| collection | DOAJ |
| description | This study aimed to identify the role of crosslinking agents in the resin–dentin bond strength (BS) when used as modifiers in adhesives or pretreatments to the dentin surface through a systematic review and meta-analysis. This paper was conducted according to the directions of the PRISMA 2020 statement. The research question of this review was: “Would the use of crosslinkers agents improve the BS of resin-based materials to dentin?” The literature search was conducted in the following databases: Embase, PubMed, Scielo, Scopus, and Web of Science. Manuscripts that reported the effect on the BS after the use of crosslinking agents were included. The meta-analyses were performed using Review Manager v5.4.1. The comparisons were performed by comparing the standardized mean difference between the BS values obtained using the crosslinker agent or the control group. The subgroup comparisons were performed based on the adhesive strategy used (total-etch or self-etch). The immediate and long-term data were analyzed separately. A total of 50 articles were included in the qualitative analysis, while 45 articles were considered for the quantitative analysis. The meta-analysis suggested that pretreatment with epigallocatechin-3-gallate (EGCG), carbodiimide, ethylenediaminetetraacetic acid (EDTA), glutaraldehyde, and riboflavin crosslinking agents improved the long-term BS of resin composites to dentin (<i>p</i> ≤ 0.02). On the other hand, the use of proanthocyanidins as a pretreatment improved both the immediate and long-term BS values (<i>p</i> ≤ 0.02). When incorporated within the adhesive formulation, only glutaraldehyde, riboflavin, and EGCG improved the long-term BS to dentin. It could be concluded that the application of different crosslinking agents such as carbodiimide, EDTA, glutaraldehyde, riboflavin, and EGCG improved the long-term BS of adhesive systems to dentin. This effect was observed when these crosslinkers were used as a separate step and when incorporated within the formulation of the adhesive system. |
| first_indexed | 2024-03-09T05:31:47Z |
| format | Article |
| id | doaj.art-ec2e8ec31e7c45d596b37aa081ec3c0f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T05:31:47Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj.art-ec2e8ec31e7c45d596b37aa081ec3c0f2023-12-03T12:32:40ZengMDPI AGCells2073-44092022-08-011115241710.3390/cells11152417Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-AnalysisLouis Hardan0Umer Daood1Rim Bourgi2Carlos Enrique Cuevas-Suárez3Walter Devoto4Maciej Zarow5Natalia Jakubowicz6Juan Eliezer Zamarripa-Calderón7Mateusz Radwanski8Giovana Orsini9Monika Lukomska-Szymanska10Department of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, LebanonClinical Dentistry, Restorative Division, Faculty of Dentistry, International Medical University Kuala Lumpur, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Wilayah Persekutuan, Kuala Lumpur 57000, MalaysiaDepartment of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, LebanonDental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, Circuito Ex Hacienda La Concepción S/N, San Agustín Tlaxiaca 42160, MexicoIndependent Researcher, 16030 Sestri Levante, Italy“NZOZ SPS Dentist” Dental Clinic and Postgraduate Course Centre, pl. Inwalidow 7/5, 30-033 Cracow, Poland“NZOZ SPS Dentist” Dental Clinic and Postgraduate Course Centre, pl. Inwalidow 7/5, 30-033 Cracow, PolandDental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, Circuito Ex Hacienda La Concepción S/N, San Agustín Tlaxiaca 42160, MexicoDepartment of Endodontics, Chair of Conservative Dentistry and Endodontics, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, PolandDepartment of Clinical Sciences and Stomatology, School of Medicine, Polytechnic University of Marche, Via Tronto 10, 60126 Ancona, ItalyDepartment of General Dentistry, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, PolandThis study aimed to identify the role of crosslinking agents in the resin–dentin bond strength (BS) when used as modifiers in adhesives or pretreatments to the dentin surface through a systematic review and meta-analysis. This paper was conducted according to the directions of the PRISMA 2020 statement. The research question of this review was: “Would the use of crosslinkers agents improve the BS of resin-based materials to dentin?” The literature search was conducted in the following databases: Embase, PubMed, Scielo, Scopus, and Web of Science. Manuscripts that reported the effect on the BS after the use of crosslinking agents were included. The meta-analyses were performed using Review Manager v5.4.1. The comparisons were performed by comparing the standardized mean difference between the BS values obtained using the crosslinker agent or the control group. The subgroup comparisons were performed based on the adhesive strategy used (total-etch or self-etch). The immediate and long-term data were analyzed separately. A total of 50 articles were included in the qualitative analysis, while 45 articles were considered for the quantitative analysis. The meta-analysis suggested that pretreatment with epigallocatechin-3-gallate (EGCG), carbodiimide, ethylenediaminetetraacetic acid (EDTA), glutaraldehyde, and riboflavin crosslinking agents improved the long-term BS of resin composites to dentin (<i>p</i> ≤ 0.02). On the other hand, the use of proanthocyanidins as a pretreatment improved both the immediate and long-term BS values (<i>p</i> ≤ 0.02). When incorporated within the adhesive formulation, only glutaraldehyde, riboflavin, and EGCG improved the long-term BS to dentin. It could be concluded that the application of different crosslinking agents such as carbodiimide, EDTA, glutaraldehyde, riboflavin, and EGCG improved the long-term BS of adhesive systems to dentin. This effect was observed when these crosslinkers were used as a separate step and when incorporated within the formulation of the adhesive system.https://www.mdpi.com/2073-4409/11/15/2417agingcollagendentin-bonding agentsproanthocyanidins |
| spellingShingle | Louis Hardan Umer Daood Rim Bourgi Carlos Enrique Cuevas-Suárez Walter Devoto Maciej Zarow Natalia Jakubowicz Juan Eliezer Zamarripa-Calderón Mateusz Radwanski Giovana Orsini Monika Lukomska-Szymanska Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis Cells aging collagen dentin-bonding agents proanthocyanidins |
| title | Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis |
| title_full | Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis |
| title_fullStr | Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis |
| title_short | Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis |
| title_sort | effect of collagen crosslinkers on dentin bond strength of adhesive systems a systematic review and meta analysis |
| topic | aging collagen dentin-bonding agents proanthocyanidins |
| url | https://www.mdpi.com/2073-4409/11/15/2417 |
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