Binding Mechanism of CD47 with SIRPα Variants and Its Antibody: Elucidated by Molecular Dynamics Simulations

Binding Mechanism of CD47 with SIRPα Variants and Its Antibody: Elucidated by Molecular Dynamics Simulations

The intricate complex system of the differentiation 47 (CD47) and the signal-regulatory protein alpha (SIRPα) cluster is a crucial target for cancer immunotherapy. Although the conformational state of the CD47-SIRPα complex has been revealed through crystallographic studies, further characterization...

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Bibliographic Details
Main Authors: Kaisheng Huang, Yi Liu, Shuixiu Wen, Yuxin Zhao, Hanjing Ding, Hui Liu, De-Xin Kong
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
tumor immune response
CD47-SIRPα
B6H12.2
molecular dynamics simulation
binding mechanism
hotspot residue
Online Access:https://www.mdpi.com/1420-3049/28/12/4610

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