Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson’s disease
Parkinson’s disease (PD) is a highly heterogeneous disorder that is difficult to diagnose. Therefore, reliable biomarkers are needed. We implemented a method constructing a regional radiomics similarity network (R2SN) based on the amplitude of low-frequency fluctuation (ALFF). We classified patients...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023015323 |
| _version_ | 1797851816430403584 |
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| author | Dafa Shi Zhendong Ren Haoran Zhang Guangsong Wang Qiu Guo Siyuan Wang Jie Ding Xiang Yao Yanfei Li Ke Ren |
| author_facet | Dafa Shi Zhendong Ren Haoran Zhang Guangsong Wang Qiu Guo Siyuan Wang Jie Ding Xiang Yao Yanfei Li Ke Ren |
| author_sort | Dafa Shi |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a highly heterogeneous disorder that is difficult to diagnose. Therefore, reliable biomarkers are needed. We implemented a method constructing a regional radiomics similarity network (R2SN) based on the amplitude of low-frequency fluctuation (ALFF). We classified patients with PD and healthy individuals by using a machine learning approach in accordance with the R2SN connectome. The ALFF-based R2SN exhibited great reproducibility with different brain atlases and datasets. Great classification performances were achieved both in primary (AUC = 0.85 ± 0.02 and accuracy = 0.81 ± 0.03) and independent external validation (AUC = 0.77 and accuracy = 0.70) datasets. The discriminative R2SN edges correlated with the clinical evaluations of patients with PD. The nodes of discriminative R2SN edges were primarily located in the default mode, sensorimotor, executive control, visual and frontoparietal network, cerebellum and striatum. These findings demonstrate that ALFF-based R2SN is a robust potential neuroimaging biomarker for PD and could provide new insights into connectome reorganization in PD. |
| first_indexed | 2024-04-09T19:23:57Z |
| format | Article |
| id | doaj.art-ec30c39d1f354c57929858d54a41c5b2 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:23:57Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ec30c39d1f354c57929858d54a41c5b22023-04-05T08:23:59ZengElsevierHeliyon2405-84402023-03-0193e14325Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson’s diseaseDafa Shi0Zhendong Ren1Haoran Zhang2Guangsong Wang3Qiu Guo4Siyuan Wang5Jie Ding6Xiang Yao7Yanfei Li8Ke Ren9Department of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China; Xiamen Key Laboratory for Endocrine-Related Cancer Precision Medicine, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China; Corresponding author. Department of Radiology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.Parkinson’s disease (PD) is a highly heterogeneous disorder that is difficult to diagnose. Therefore, reliable biomarkers are needed. We implemented a method constructing a regional radiomics similarity network (R2SN) based on the amplitude of low-frequency fluctuation (ALFF). We classified patients with PD and healthy individuals by using a machine learning approach in accordance with the R2SN connectome. The ALFF-based R2SN exhibited great reproducibility with different brain atlases and datasets. Great classification performances were achieved both in primary (AUC = 0.85 ± 0.02 and accuracy = 0.81 ± 0.03) and independent external validation (AUC = 0.77 and accuracy = 0.70) datasets. The discriminative R2SN edges correlated with the clinical evaluations of patients with PD. The nodes of discriminative R2SN edges were primarily located in the default mode, sensorimotor, executive control, visual and frontoparietal network, cerebellum and striatum. These findings demonstrate that ALFF-based R2SN is a robust potential neuroimaging biomarker for PD and could provide new insights into connectome reorganization in PD.http://www.sciencedirect.com/science/article/pii/S2405844023015323Amplitude of low-frequency fluctuation (ALFF)BiomarkerNetworkMachine learningParkinson’s disease |
| spellingShingle | Dafa Shi Zhendong Ren Haoran Zhang Guangsong Wang Qiu Guo Siyuan Wang Jie Ding Xiang Yao Yanfei Li Ke Ren Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson’s disease Heliyon Amplitude of low-frequency fluctuation (ALFF) Biomarker Network Machine learning Parkinson’s disease |
| title | Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson’s disease |
| title_full | Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson’s disease |
| title_fullStr | Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson’s disease |
| title_full_unstemmed | Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson’s disease |
| title_short | Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson’s disease |
| title_sort | amplitude of low frequency fluctuation based regional radiomics similarity network biomarker for parkinson s disease |
| topic | Amplitude of low-frequency fluctuation (ALFF) Biomarker Network Machine learning Parkinson’s disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023015323 |
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