Integrating high-throughput analysis to create an atlas of replication origins in Trypanosoma cruzi in the context of genome structure and variability

Integrating high-throughput analysis to create an atlas of replication origins in Trypanosoma cruzi in the context of genome structure and variability

ABSTRACTTrypanosoma cruzi is the etiologic agent of the most prevalent human parasitic disease in Latin America, Chagas disease. Its genome is rich in multigenic families that code for virulent antigens and are present in the rapidly evolving genomic compartment named Disruptive. DNA replication is...

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Main Authors: Marcela de Oliveira Vitarelli, Thiago Andrade Franco, David da Silva Pires, Alex Ranieri Jerônimo Lima, Vincent Louis Viala, Amelie Johanna Kraus, Inácio de Loiola Meirelles Junqueira de Azevedo, Julia Pinheiro Chagas da Cunha, Maria Carolina Elias
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
replication origins
prereplication complex
Trypanosoma cruzi
DNA replication
Online Access:https://journals.asm.org/doi/10.1128/mbio.00319-24

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