Hepatoprotective Role of α-Lipoic acid and Thymoquinone in Acetaminophen- Induced Liver Injury: Down-Regulation of COX-2 and flt-1 Expression

Hepatoprotective Role of α-Lipoic acid and Thymoquinone in Acetaminophen- Induced Liver Injury: Down-Regulation of COX-2 and flt-1 Expression

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ABSTRACT Acetaminophen (APAP) is a widely-used analgesic, while toxic doses of which induce liver injury. Inducible cyclooxygenase-2 (COX-2) is derived prostaglandins which play an anti-inflammatory role in acetaminophen-induced hepatotoxicity. Selective activation of vascular endothelial growth fac...

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Bibliographic Details
Main Authors: Nawal M. Al-Rasheed, Laila Fadda, Nouf M. Al-Rasheed, Iman H. Hasan, Hanaa M. Ali, Musaed Al-Fayez, Raeesa A. Mohamad
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2017-08-01
Series:Brazilian Archives of Biology and Technology
Subjects:
Acetaminophen
α-Lipoic acid
Thymoquinone
cyclooxygenase-2
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100427&lng=en&tlng=en

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