Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32
Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5–7, and 9–12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher’s and Marfey’s methods, along with qu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-10-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/13/10/6489 |
| _version_ | 1828280967511408640 |
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| author | Ya-Qin Fan Pei-Hai Li Ya-Xi Chao Hao Chen Ning Du Qiu-Xia He Ke-Chun Liu |
| author_facet | Ya-Qin Fan Pei-Hai Li Ya-Xi Chao Hao Chen Ning Du Qiu-Xia He Ke-Chun Liu |
| author_sort | Ya-Qin Fan |
| collection | DOAJ |
| description | Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5–7, and 9–12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher’s and Marfey’s methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model. All of the compounds showed a significant mitigative effect on bradycardia caused by astemizole (ASM) in the heart rate experiments. Compounds 4–6 and 8–12 exhibited potent vasculogenetic activity in vasculogenesis experiments. This is the first study to report that these types of compounds show cardiovascular effects in zebrafish. The results suggest that these compounds could be promising candidates for cardiovascular disease lead compounds. |
| first_indexed | 2024-04-13T08:07:29Z |
| format | Article |
| id | doaj.art-ec32405d2bb140e6a65ab2709cbcb97d |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T08:07:29Z |
| publishDate | 2015-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ec32405d2bb140e6a65ab2709cbcb97d2022-12-22T02:55:06ZengMDPI AGMarine Drugs1660-33972015-10-0113106489650410.3390/md13106489md13106489Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32Ya-Qin Fan0Pei-Hai Li1Ya-Xi Chao2Hao Chen3Ning Du4Qiu-Xia He5Ke-Chun Liu6Key Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, ChinaKey Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, ChinaKey Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, ChinaKey Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, ChinaKey Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, ChinaInstitute of Biology, Shandong Academy of SciencesInstitute of Biology, Shandong Academy of SciencesThree new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5–7, and 9–12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher’s and Marfey’s methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model. All of the compounds showed a significant mitigative effect on bradycardia caused by astemizole (ASM) in the heart rate experiments. Compounds 4–6 and 8–12 exhibited potent vasculogenetic activity in vasculogenesis experiments. This is the first study to report that these types of compounds show cardiovascular effects in zebrafish. The results suggest that these compounds could be promising candidates for cardiovascular disease lead compounds.http://www.mdpi.com/1660-3397/13/10/6489marine-derived fungusPenicillium expansumsecondary metabolitesalkaloidscardiovascular effects |
| spellingShingle | Ya-Qin Fan Pei-Hai Li Ya-Xi Chao Hao Chen Ning Du Qiu-Xia He Ke-Chun Liu Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32 Marine Drugs marine-derived fungus Penicillium expansum secondary metabolites alkaloids cardiovascular effects |
| title | Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32 |
| title_full | Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32 |
| title_fullStr | Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32 |
| title_full_unstemmed | Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32 |
| title_short | Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32 |
| title_sort | alkaloids with cardiovascular effects from the marine derived fungus penicillium expansum y32 |
| topic | marine-derived fungus Penicillium expansum secondary metabolites alkaloids cardiovascular effects |
| url | http://www.mdpi.com/1660-3397/13/10/6489 |
| work_keys_str_mv | AT yaqinfan alkaloidswithcardiovasculareffectsfromthemarinederivedfunguspenicilliumexpansumy32 AT peihaili alkaloidswithcardiovasculareffectsfromthemarinederivedfunguspenicilliumexpansumy32 AT yaxichao alkaloidswithcardiovasculareffectsfromthemarinederivedfunguspenicilliumexpansumy32 AT haochen alkaloidswithcardiovasculareffectsfromthemarinederivedfunguspenicilliumexpansumy32 AT ningdu alkaloidswithcardiovasculareffectsfromthemarinederivedfunguspenicilliumexpansumy32 AT qiuxiahe alkaloidswithcardiovasculareffectsfromthemarinederivedfunguspenicilliumexpansumy32 AT kechunliu alkaloidswithcardiovasculareffectsfromthemarinederivedfunguspenicilliumexpansumy32 |