Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay

Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay

Abstract Background More than half of the colorectal cancer (CRC) patients will develop liver metastasis that underlies the cancer mortality. In the hepatic tumor microenvironment, the interplay between CRC cells and hepatic stellate cells (HSCs), and the activation of HSCs to become carcinoma-assoc...

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Bibliographic Details
Main Authors: Xueying Fan, Mingjing Meng, Baoting Li, Hui Chen, Jincheng Tan, Keyang Xu, Shilin Xiao, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Translational Medicine
Subjects:
Brevilin A
Liver metastases of colorectal cancer
HSCs-CRC interplay
Carcinoma-associated fibroblasts
VEGF-IL6-STAT3 axis
Online Access:https://doi.org/10.1186/s12967-023-04087-6

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