The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milk
Introduction: Forty-four percent of lactating women in the United States consume beverages containing low calorie sweeteners (LCS), and the presence of LCS in the food supply has continued to increase in recent years. While LCS are approved by the United States Food and Drug Administration (FDA) and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Contemporary Clinical Trials Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865423001588 |
| _version_ | 1797389445459083264 |
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| author | Brooke Langevin Mathangi Gopalakrishnan Janae Kuttamperoor John Van Den Anker Jeanne Murphy Kathleen F. Arcaro Dina Daines Allison C. Sylvetsky |
| author_facet | Brooke Langevin Mathangi Gopalakrishnan Janae Kuttamperoor John Van Den Anker Jeanne Murphy Kathleen F. Arcaro Dina Daines Allison C. Sylvetsky |
| author_sort | Brooke Langevin |
| collection | DOAJ |
| description | Introduction: Forty-four percent of lactating women in the United States consume beverages containing low calorie sweeteners (LCS), and the presence of LCS in the food supply has continued to increase in recent years. While LCS are approved by the United States Food and Drug Administration (FDA) and are believed to be safe for human consumption, intergenerational LCS transmission and the health impacts of early life LCS exposure are severely understudied. Methods and analysis: In a tightly controlled, single site, prospective interventional study, mothers' plasma and breast milk, and infants’ plasma will be collected from 40 mother-infant dyads over the course of 72 h, with rich sampling following maternal ingestion of a LCS sweetened beverage containing sucralose and acesulfame potassium (ace-K). Concentration-time data will be used to build maternal and infant pharmacokinetic models for future simulations and analysis. Conclusion: This study aims to measure LCS concentrations in breast milk, maternal plasma, and infant plasma, to gain insight into infant exposure and inform recommendations for LCS consumption during breastfeeding. |
| first_indexed | 2024-03-08T22:57:03Z |
| format | Article |
| id | doaj.art-ec35809f12ff47c5a4975537c56a6194 |
| institution | Directory Open Access Journal |
| issn | 2451-8654 |
| language | English |
| last_indexed | 2024-03-08T22:57:03Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj.art-ec35809f12ff47c5a4975537c56a61942023-12-16T06:08:35ZengElsevierContemporary Clinical Trials Communications2451-86542023-12-0136101212The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milkBrooke Langevin0Mathangi Gopalakrishnan1Janae Kuttamperoor2John Van Den Anker3Jeanne Murphy4Kathleen F. Arcaro5Dina Daines6Allison C. Sylvetsky7Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, USACenter for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, USA; Corresponding author. Center for Translational Medicine, University of Maryland School of Pharmacy, 20 N Pine St, N517, Baltimore, Maryland, 21201, USA.Department of Exercise and Nutrition Sciences, The George Washington University, Washington D.C., USADivision of Clinical Pharmacology, Children's National Medical Center, Washington D.C., USASchool of Nursing, The George Washington University, Washington D.C., USADepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, USADepartment of Obstetrics and Gynecology, The George Washington University, Washington D.C., USADepartment of Exercise and Nutrition Sciences, The George Washington University, Washington D.C., USA; Corresponding author. Department of Exercise and Nutrition Sciences, The George Washington University, 950 New Hampshire Avenue NW, Suite 200, Washington DC, 20052, USA.Introduction: Forty-four percent of lactating women in the United States consume beverages containing low calorie sweeteners (LCS), and the presence of LCS in the food supply has continued to increase in recent years. While LCS are approved by the United States Food and Drug Administration (FDA) and are believed to be safe for human consumption, intergenerational LCS transmission and the health impacts of early life LCS exposure are severely understudied. Methods and analysis: In a tightly controlled, single site, prospective interventional study, mothers' plasma and breast milk, and infants’ plasma will be collected from 40 mother-infant dyads over the course of 72 h, with rich sampling following maternal ingestion of a LCS sweetened beverage containing sucralose and acesulfame potassium (ace-K). Concentration-time data will be used to build maternal and infant pharmacokinetic models for future simulations and analysis. Conclusion: This study aims to measure LCS concentrations in breast milk, maternal plasma, and infant plasma, to gain insight into infant exposure and inform recommendations for LCS consumption during breastfeeding.http://www.sciencedirect.com/science/article/pii/S2451865423001588Low calorie sweetenersSucraloseAcesulfame-potassiumIntergenerational transmissionPharmacometrics |
| spellingShingle | Brooke Langevin Mathangi Gopalakrishnan Janae Kuttamperoor John Van Den Anker Jeanne Murphy Kathleen F. Arcaro Dina Daines Allison C. Sylvetsky The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milk Contemporary Clinical Trials Communications Low calorie sweeteners Sucralose Acesulfame-potassium Intergenerational transmission Pharmacometrics |
| title | The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milk |
| title_full | The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milk |
| title_fullStr | The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milk |
| title_full_unstemmed | The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milk |
| title_short | The MILK study: Investigating intergenerational transmission of low-calorie sweeteners in breast milk |
| title_sort | milk study investigating intergenerational transmission of low calorie sweeteners in breast milk |
| topic | Low calorie sweeteners Sucralose Acesulfame-potassium Intergenerational transmission Pharmacometrics |
| url | http://www.sciencedirect.com/science/article/pii/S2451865423001588 |
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