Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome
Abstract Background Nicolaides–Baraitser syndrome (NCBRS) is a rare disorder characterized by neurodevelopmental delays, seizures, and diverse physical characteristics. The DNA methylation (DNAm) profile in NCBRS is significantly different. DNAm is linked to the biological aging of cells and the hea...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Molecular Genetics & Genomic Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mgg3.1876 |
| _version_ | 1818532684225314816 |
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| author | Yutaka Shinko Satoshi Okazaki Ikuo Otsuka Tadasu Horai Saehyeon Kim Takaki Tanifuji Akitoyo Hishimoto |
| author_facet | Yutaka Shinko Satoshi Okazaki Ikuo Otsuka Tadasu Horai Saehyeon Kim Takaki Tanifuji Akitoyo Hishimoto |
| author_sort | Yutaka Shinko |
| collection | DOAJ |
| description | Abstract Background Nicolaides–Baraitser syndrome (NCBRS) is a rare disorder characterized by neurodevelopmental delays, seizures, and diverse physical characteristics. The DNA methylation (DNAm) profile in NCBRS is significantly different. DNAm is linked to the biological aging of cells and the health risks associated with biological aging. In this study, we examined changes in biological ages in NCBRS to provide insights into the prognosis and health risks of NCBRS. Methods We used a publicly available dataset to examine biological aging in NCBRS using DNAm‐based epigenetic ages, such as PhenoAge and GrimAge, as well as DNAm‐based estimator of telomere length (DNAmTL). We investigated 12 cases, clinically diagnosed as NCBRS, and 27 controls. Results Compared to controls, NCBRS cases exhibited significantly accelerated PhenoAge and GrimAge as well as significantly shortened DNAmTL. Conclusion These results suggest an acceleration of biological aging in NCBRS and provide insights into the prognosis and health risks of NCBRS. |
| first_indexed | 2024-12-11T17:48:44Z |
| format | Article |
| id | doaj.art-ec35f7ffb3ae428095d55693e5939c50 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-12-11T17:48:44Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-ec35f7ffb3ae428095d55693e5939c502022-12-22T00:56:17ZengWileyMolecular Genetics & Genomic Medicine2324-92692022-03-01103n/an/a10.1002/mgg3.1876Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndromeYutaka Shinko0Satoshi Okazaki1Ikuo Otsuka2Tadasu Horai3Saehyeon Kim4Takaki Tanifuji5Akitoyo Hishimoto6Department of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanAbstract Background Nicolaides–Baraitser syndrome (NCBRS) is a rare disorder characterized by neurodevelopmental delays, seizures, and diverse physical characteristics. The DNA methylation (DNAm) profile in NCBRS is significantly different. DNAm is linked to the biological aging of cells and the health risks associated with biological aging. In this study, we examined changes in biological ages in NCBRS to provide insights into the prognosis and health risks of NCBRS. Methods We used a publicly available dataset to examine biological aging in NCBRS using DNAm‐based epigenetic ages, such as PhenoAge and GrimAge, as well as DNAm‐based estimator of telomere length (DNAmTL). We investigated 12 cases, clinically diagnosed as NCBRS, and 27 controls. Results Compared to controls, NCBRS cases exhibited significantly accelerated PhenoAge and GrimAge as well as significantly shortened DNAmTL. Conclusion These results suggest an acceleration of biological aging in NCBRS and provide insights into the prognosis and health risks of NCBRS.https://doi.org/10.1002/mgg3.1876DNA methylationepigenetic ageNicolaides–Baraitser syndrometelomere length |
| spellingShingle | Yutaka Shinko Satoshi Okazaki Ikuo Otsuka Tadasu Horai Saehyeon Kim Takaki Tanifuji Akitoyo Hishimoto Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome Molecular Genetics & Genomic Medicine DNA methylation epigenetic age Nicolaides–Baraitser syndrome telomere length |
| title | Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome |
| title_full | Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome |
| title_fullStr | Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome |
| title_full_unstemmed | Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome |
| title_short | Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome |
| title_sort | accelerated epigenetic age and shortened telomere length based on dna methylation in nicolaides baraitser syndrome |
| topic | DNA methylation epigenetic age Nicolaides–Baraitser syndrome telomere length |
| url | https://doi.org/10.1002/mgg3.1876 |
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