Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome

Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome

Abstract Background Nicolaides–Baraitser syndrome (NCBRS) is a rare disorder characterized by neurodevelopmental delays, seizures, and diverse physical characteristics. The DNA methylation (DNAm) profile in NCBRS is significantly different. DNAm is linked to the biological aging of cells and the hea...

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Bibliographic Details
Main Authors: Yutaka Shinko, Satoshi Okazaki, Ikuo Otsuka, Tadasu Horai, Saehyeon Kim, Takaki Tanifuji, Akitoyo Hishimoto
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
DNA methylation
epigenetic age
Nicolaides–Baraitser syndrome
telomere length
Online Access:https://doi.org/10.1002/mgg3.1876

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