Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease
BackgroundSimultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a novel hybrid imaging method integrating the advances of morphological tissue characterization of MRI with the pathophysiological insights of PET applications.AimThis study evaluated the use of simulta...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1352696/full |
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| author | Tobias Koppara Tobias Koppara Isabel Dregely Stephan G. Nekolla Stephan G. Nekolla Jörg Nährig Nicolas Langwieser Christian Bradaric Carl Ganter Karl-Ludwig Laugwitz Karl-Ludwig Laugwitz Markus Schwaiger Markus Schwaiger Tareq Ibrahim |
| author_facet | Tobias Koppara Tobias Koppara Isabel Dregely Stephan G. Nekolla Stephan G. Nekolla Jörg Nährig Nicolas Langwieser Christian Bradaric Carl Ganter Karl-Ludwig Laugwitz Karl-Ludwig Laugwitz Markus Schwaiger Markus Schwaiger Tareq Ibrahim |
| author_sort | Tobias Koppara |
| collection | DOAJ |
| description | BackgroundSimultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a novel hybrid imaging method integrating the advances of morphological tissue characterization of MRI with the pathophysiological insights of PET applications.AimThis study evaluated the use of simultaneous 18-FDG PET/MR imaging for characterizing atherosclerotic lesions in lower extremity arterial disease (LEAD).MethodsEight patients with symptomatic stenoses of the superficial femoral artery (SFA) under simultaneous acquisition of 18-FDG PET and contrast-enhanced MRI using an integrated whole-body PET/MRI scanner. Invasive plaque characterization of the SFA was performed by intravascular imaging using optical coherence tomography. Histological analysis of plaque specimens was performed after directional atherectomy.ResultsMRI showed contrast enhancement at the site of arterial stenosis, as assessed on T2-w and T1-w images, compared to a control area of the contralateral SFA (0.38 ± 0.15 cm vs. 0.23 ± 0.11 cm; 1.77 ± 0.19 vs. 1.57 ± 0.15; p-value <0.05). On PET imaging, uptake of 18F-FDG (target-to-background ratio TBR > 1) at the level of symptomatic stenosis was observed in all but one patient. Contrast medium-induced MR signal enhancement was detected in all plaques, whereas FDG uptake in PET imaging was increased in lesions with active fibroatheroma and reduced in fibrocalcified lesions.ConclusionIn this multimodal imaging study, we report the feasibility and challenges of simultaneous PET/MR imaging of LEAD, which might offer new perspectives for risk estimation. |
| first_indexed | 2024-03-08T04:06:08Z |
| format | Article |
| id | doaj.art-ec37c33fd7c44a4996b11225d72ec30d |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T04:06:08Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-ec37c33fd7c44a4996b11225d72ec30d2024-02-09T05:05:12ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-02-011110.3389/fcvm.2024.13526961352696Simultaneous 18-FDG PET and MR imaging in lower extremity arterial diseaseTobias Koppara0Tobias Koppara1Isabel Dregely2Stephan G. Nekolla3Stephan G. Nekolla4Jörg Nährig5Nicolas Langwieser6Christian Bradaric7Carl Ganter8Karl-Ludwig Laugwitz9Karl-Ludwig Laugwitz10Markus Schwaiger11Markus Schwaiger12Tareq Ibrahim13Department of Internal Medicine I, Cardiology and Angiology, School of Medicine and Health, Technical University of Munich, Munich, GermanyDZHK (German Center for Cardiovascular Research)—Partner Site Munich Heart Alliance, Munich, GermanyDepartment of Nuclear Medicine, School of Medicine and Health, Technical University of Munich, Munich, GermanyDZHK (German Center for Cardiovascular Research)—Partner Site Munich Heart Alliance, Munich, GermanyDepartment of Nuclear Medicine, School of Medicine and Health, Technical University of Munich, Munich, GermanyInstitute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, GermanyDepartment of Internal Medicine I, Cardiology and Angiology, School of Medicine and Health, Technical University of Munich, Munich, GermanyDepartment of Internal Medicine I, Cardiology and Angiology, School of Medicine and Health, Technical University of Munich, Munich, GermanyInstitute of Radiology, School of Medicine and Health, Technical University of Munich, Munich, GermanyDepartment of Internal Medicine I, Cardiology and Angiology, School of Medicine and Health, Technical University of Munich, Munich, GermanyDZHK (German Center for Cardiovascular Research)—Partner Site Munich Heart Alliance, Munich, GermanyDZHK (German Center for Cardiovascular Research)—Partner Site Munich Heart Alliance, Munich, GermanyDepartment of Nuclear Medicine, School of Medicine and Health, Technical University of Munich, Munich, GermanyDepartment of Internal Medicine I, Cardiology and Angiology, School of Medicine and Health, Technical University of Munich, Munich, GermanyBackgroundSimultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a novel hybrid imaging method integrating the advances of morphological tissue characterization of MRI with the pathophysiological insights of PET applications.AimThis study evaluated the use of simultaneous 18-FDG PET/MR imaging for characterizing atherosclerotic lesions in lower extremity arterial disease (LEAD).MethodsEight patients with symptomatic stenoses of the superficial femoral artery (SFA) under simultaneous acquisition of 18-FDG PET and contrast-enhanced MRI using an integrated whole-body PET/MRI scanner. Invasive plaque characterization of the SFA was performed by intravascular imaging using optical coherence tomography. Histological analysis of plaque specimens was performed after directional atherectomy.ResultsMRI showed contrast enhancement at the site of arterial stenosis, as assessed on T2-w and T1-w images, compared to a control area of the contralateral SFA (0.38 ± 0.15 cm vs. 0.23 ± 0.11 cm; 1.77 ± 0.19 vs. 1.57 ± 0.15; p-value <0.05). On PET imaging, uptake of 18F-FDG (target-to-background ratio TBR > 1) at the level of symptomatic stenosis was observed in all but one patient. Contrast medium-induced MR signal enhancement was detected in all plaques, whereas FDG uptake in PET imaging was increased in lesions with active fibroatheroma and reduced in fibrocalcified lesions.ConclusionIn this multimodal imaging study, we report the feasibility and challenges of simultaneous PET/MR imaging of LEAD, which might offer new perspectives for risk estimation.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1352696/fulloptical coherence tomographymagnetic resonance imaging (MRI)FDG PET = F-18 fluorodeoxyglucose positron emission tomographyatherectomyperipheral arterial disease |
| spellingShingle | Tobias Koppara Tobias Koppara Isabel Dregely Stephan G. Nekolla Stephan G. Nekolla Jörg Nährig Nicolas Langwieser Christian Bradaric Carl Ganter Karl-Ludwig Laugwitz Karl-Ludwig Laugwitz Markus Schwaiger Markus Schwaiger Tareq Ibrahim Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease Frontiers in Cardiovascular Medicine optical coherence tomography magnetic resonance imaging (MRI) FDG PET = F-18 fluorodeoxyglucose positron emission tomography atherectomy peripheral arterial disease |
| title | Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease |
| title_full | Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease |
| title_fullStr | Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease |
| title_full_unstemmed | Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease |
| title_short | Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease |
| title_sort | simultaneous 18 fdg pet and mr imaging in lower extremity arterial disease |
| topic | optical coherence tomography magnetic resonance imaging (MRI) FDG PET = F-18 fluorodeoxyglucose positron emission tomography atherectomy peripheral arterial disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1352696/full |
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