Research advances on the mechanism of macrophage polarization in renal interstitial fibrosis
Renal interstitial fibrosis (RIF) is a common pathological process for many chronic kidney diseases (CKD). As heterogeneous cells capable of promoting the occurrence and development of RIF, macrophages are the major driving factors of end-stage renal disease (ESRD). Although its pathogenic role in r...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2023-11-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2023.11.013 |
| _version_ | 1827344748365479936 |
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| author | Ke-li Gao Jing Yang Yong-jun Zhu |
| author_facet | Ke-li Gao Jing Yang Yong-jun Zhu |
| author_sort | Ke-li Gao |
| collection | DOAJ |
| description | Renal interstitial fibrosis (RIF) is a common pathological process for many chronic kidney diseases (CKD). As heterogeneous cells capable of promoting the occurrence and development of RIF, macrophages are the major driving factors of end-stage renal disease (ESRD). Although its pathogenic role in renal inflammation and fibrosis is widely recognized, it also plays some key role in tissue remodeling, repairing and immune regulation. Under the stimulation of microenvironment, macrophages may polarize into various phenotypes (mainly M1 & M2), thus exerting pro-inflammatory and anti-inflammatory effects. Recent studies have confirmed that these two phenotypes may regulate inflammation and promote tissue repair in chronic kidney diseases, acting as potential therapeutic targets of RIF. Therefore understanding the role of different macrophage phenotypes during renal injury and repair is vital for elucidating molecular mechanism and a proper treatment of RIF. Furthermore, the exact role of macrophages in various aspects of RIF should be further explored. |
| first_indexed | 2024-03-07T22:51:55Z |
| format | Article |
| id | doaj.art-ec3974d397354ab6b934922db4b150b0 |
| institution | Directory Open Access Journal |
| issn | 1671-2390 |
| language | zho |
| last_indexed | 2024-03-07T22:51:55Z |
| publishDate | 2023-11-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj.art-ec3974d397354ab6b934922db4b150b02024-02-23T09:28:24ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902023-11-01231196196610.3969/j.issn.1671-2390.2023.11.01320230046Research advances on the mechanism of macrophage polarization in renal interstitial fibrosisKe-li Gao0Jing Yang1Yong-jun Zhu2First Affiliated Hospital, Hainan Medical University, Haikou 570102, ChinaFirst Affiliated Hospital, Hainan Medical University, Haikou 570102, ChinaFirst Affiliated Hospital, Hainan Medical University, Haikou 570102, ChinaRenal interstitial fibrosis (RIF) is a common pathological process for many chronic kidney diseases (CKD). As heterogeneous cells capable of promoting the occurrence and development of RIF, macrophages are the major driving factors of end-stage renal disease (ESRD). Although its pathogenic role in renal inflammation and fibrosis is widely recognized, it also plays some key role in tissue remodeling, repairing and immune regulation. Under the stimulation of microenvironment, macrophages may polarize into various phenotypes (mainly M1 & M2), thus exerting pro-inflammatory and anti-inflammatory effects. Recent studies have confirmed that these two phenotypes may regulate inflammation and promote tissue repair in chronic kidney diseases, acting as potential therapeutic targets of RIF. Therefore understanding the role of different macrophage phenotypes during renal injury and repair is vital for elucidating molecular mechanism and a proper treatment of RIF. Furthermore, the exact role of macrophages in various aspects of RIF should be further explored.http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2023.11.013chronic kidney diseasesrenal interstitial fibrosismacrophagespolarization |
| spellingShingle | Ke-li Gao Jing Yang Yong-jun Zhu Research advances on the mechanism of macrophage polarization in renal interstitial fibrosis Linchuang shenzangbing zazhi chronic kidney diseases renal interstitial fibrosis macrophages polarization |
| title | Research advances on the mechanism of macrophage polarization in renal interstitial fibrosis |
| title_full | Research advances on the mechanism of macrophage polarization in renal interstitial fibrosis |
| title_fullStr | Research advances on the mechanism of macrophage polarization in renal interstitial fibrosis |
| title_full_unstemmed | Research advances on the mechanism of macrophage polarization in renal interstitial fibrosis |
| title_short | Research advances on the mechanism of macrophage polarization in renal interstitial fibrosis |
| title_sort | research advances on the mechanism of macrophage polarization in renal interstitial fibrosis |
| topic | chronic kidney diseases renal interstitial fibrosis macrophages polarization |
| url | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2023.11.013 |
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