A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation
Stress is a disturbance in homeostasis caused by psychological, physiological, or environmental factors. Prolonged reactions to chronic stress can be detrimental, resulting in various metabolic abnormalities, referred to as metabolic syndrome (MS). There is a reciprocal increased risk between MS and...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580823001528 |
| _version_ | 1797422606240972800 |
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| author | Seema Mehdi Shahid Ud Din Wani K.L. Krishna Nabeel Kinattingal Tamsheel Fatima Roohi |
| author_facet | Seema Mehdi Shahid Ud Din Wani K.L. Krishna Nabeel Kinattingal Tamsheel Fatima Roohi |
| author_sort | Seema Mehdi |
| collection | DOAJ |
| description | Stress is a disturbance in homeostasis caused by psychological, physiological, or environmental factors. Prolonged reactions to chronic stress can be detrimental, resulting in various metabolic abnormalities, referred to as metabolic syndrome (MS). There is a reciprocal increased risk between MS and major depressive disorder. Recent studies established an association between inflammation and insulin signaling in type 2 diabetes mellitus with depression. In the present review, we discuss chronic low-grade inflammation, pathways of insulin resistance, and brain glucose metabolism in the context of neuroinflammation and depression. Specific attention is given to psychotropic drugs such as bupropion, mirtazapine, and nefazodone, anti-inflammatory drugs like Celecoxib (COX-2 inhibitor), Etanercept, adalimumab, IL-4Ra antagonist, Anti-IL- 17A antibody (Ixekizumab) and lifestyle modifications including exercise, dietary changes, and sleep hygiene. These therapeutic solutions offer potential in treating depression by targeting metabolic conditions like insulin resistance and inflammatory pathways. The article further explains the significance of a nutrition and antioxidants-rich diet, emphasizing the role of omega-3 fatty acids, vitamin D, zinc, and polyphenols, to improve immunity and activate anti-inflammatory signaling pathways. |
| first_indexed | 2024-03-09T07:34:45Z |
| format | Article |
| id | doaj.art-ec399916a83049beb0c6d759ee4f1415 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-03-09T07:34:45Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-ec399916a83049beb0c6d759ee4f14152023-12-03T05:41:57ZengElsevierBiochemistry and Biophysics Reports2405-58082023-12-0136101571A review on linking stress, depression, and insulin resistance via low-grade chronic inflammationSeema Mehdi0Shahid Ud Din Wani1K.L. Krishna2Nabeel Kinattingal3Tamsheel Fatima Roohi4Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysore, 570 015, India; Corresponding author. Department of Pharmacology, JSS College of Pharmacy, JSS Academy for Higher Education and Research, Mysore, 570015, Karnataka, India.Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, IndiaDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysore, 570 015, India; Corresponding author.Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysore, 570 015, IndiaDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysore, 570 015, IndiaStress is a disturbance in homeostasis caused by psychological, physiological, or environmental factors. Prolonged reactions to chronic stress can be detrimental, resulting in various metabolic abnormalities, referred to as metabolic syndrome (MS). There is a reciprocal increased risk between MS and major depressive disorder. Recent studies established an association between inflammation and insulin signaling in type 2 diabetes mellitus with depression. In the present review, we discuss chronic low-grade inflammation, pathways of insulin resistance, and brain glucose metabolism in the context of neuroinflammation and depression. Specific attention is given to psychotropic drugs such as bupropion, mirtazapine, and nefazodone, anti-inflammatory drugs like Celecoxib (COX-2 inhibitor), Etanercept, adalimumab, IL-4Ra antagonist, Anti-IL- 17A antibody (Ixekizumab) and lifestyle modifications including exercise, dietary changes, and sleep hygiene. These therapeutic solutions offer potential in treating depression by targeting metabolic conditions like insulin resistance and inflammatory pathways. The article further explains the significance of a nutrition and antioxidants-rich diet, emphasizing the role of omega-3 fatty acids, vitamin D, zinc, and polyphenols, to improve immunity and activate anti-inflammatory signaling pathways.http://www.sciencedirect.com/science/article/pii/S2405580823001528Major depressive disorderLow-grade chronic inflammationChronic stressInsulin resistanceMetabolic syndromeNeurodegeneration |
| spellingShingle | Seema Mehdi Shahid Ud Din Wani K.L. Krishna Nabeel Kinattingal Tamsheel Fatima Roohi A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation Biochemistry and Biophysics Reports Major depressive disorder Low-grade chronic inflammation Chronic stress Insulin resistance Metabolic syndrome Neurodegeneration |
| title | A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation |
| title_full | A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation |
| title_fullStr | A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation |
| title_full_unstemmed | A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation |
| title_short | A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation |
| title_sort | review on linking stress depression and insulin resistance via low grade chronic inflammation |
| topic | Major depressive disorder Low-grade chronic inflammation Chronic stress Insulin resistance Metabolic syndrome Neurodegeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2405580823001528 |
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