| Summary: | A new 1D Ni(II) coordination polymer was synthesized by the reaction of NiSO<sub>4</sub>·6H<sub>2</sub>O with 2,4-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPT) and SCN<sup>−</sup> as a linker in an acidic medium by heating under reflux conditions. Unusually, the BPT ligand underwent acid-mediated hydrolysis by losing one of the pyrazolyl arms afforded the polymeric [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex (MPT: 4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazin-2-ol. The Ni(II) center is coordinated with one MPT as a bidentate <i>NN</i>-chelate, one water molecule, and two thiocyanate groups in <i>cis</i> positions to one another. One of the thiocyanate groups acts as a bridging ligand between metal centers, leading to a one-dimensional polymeric structure that extends along the <i>c</i>-direction. The other thiocyanate group is terminally N-coordinated. The [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex has been screened in vitro against two pathogenic fungal strains: <i>A. fumigatus</i>, <i>C. albican</i>, and four pathogenic bacterial strains: <i>S. aureus</i>, <i>B. subtilis</i> as gram-positive bacteria, <i>E. coli</i>, <i>P. vulgaris</i> as gram-negative bacteria. The results showed that the complex has the potential to be used as both an antibacterial and an antifungal agent. Also, the [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex showed cytotoxic activities against hepatocellular (HepG-2) and lung (A-549) cell lines, with IC<sub>50</sub> values of 132.67 ± 5.14 and 146.97 ± 7.34 μM, respectively.
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