A New 1D Ni (II) Coordination Polymer of <i>s</i>-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-<i>Bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine
A new 1D Ni(II) coordination polymer was synthesized by the reaction of NiSO<sub>4</sub>·6H<sub>2</sub>O with 2,4-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPT) and SCN<sup>−</sup> as a linker in an acidic me...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/11/3/135 |
| _version_ | 1797611138501836800 |
|---|---|
| author | Kholood A. Dahlous Saied M. Soliman Matti Haukka Ayman El-Faham Raghdaa A. Massoud |
| author_facet | Kholood A. Dahlous Saied M. Soliman Matti Haukka Ayman El-Faham Raghdaa A. Massoud |
| author_sort | Kholood A. Dahlous |
| collection | DOAJ |
| description | A new 1D Ni(II) coordination polymer was synthesized by the reaction of NiSO<sub>4</sub>·6H<sub>2</sub>O with 2,4-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPT) and SCN<sup>−</sup> as a linker in an acidic medium by heating under reflux conditions. Unusually, the BPT ligand underwent acid-mediated hydrolysis by losing one of the pyrazolyl arms afforded the polymeric [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex (MPT: 4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazin-2-ol. The Ni(II) center is coordinated with one MPT as a bidentate <i>NN</i>-chelate, one water molecule, and two thiocyanate groups in <i>cis</i> positions to one another. One of the thiocyanate groups acts as a bridging ligand between metal centers, leading to a one-dimensional polymeric structure that extends along the <i>c</i>-direction. The other thiocyanate group is terminally N-coordinated. The [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex has been screened in vitro against two pathogenic fungal strains: <i>A. fumigatus</i>, <i>C. albican</i>, and four pathogenic bacterial strains: <i>S. aureus</i>, <i>B. subtilis</i> as gram-positive bacteria, <i>E. coli</i>, <i>P. vulgaris</i> as gram-negative bacteria. The results showed that the complex has the potential to be used as both an antibacterial and an antifungal agent. Also, the [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex showed cytotoxic activities against hepatocellular (HepG-2) and lung (A-549) cell lines, with IC<sub>50</sub> values of 132.67 ± 5.14 and 146.97 ± 7.34 μM, respectively. |
| first_indexed | 2024-03-11T06:23:35Z |
| format | Article |
| id | doaj.art-ec3e198354ec4c0081c403798a25c015 |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-11T06:23:35Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-ec3e198354ec4c0081c403798a25c0152023-11-17T11:45:28ZengMDPI AGInorganics2304-67402023-03-0111313510.3390/inorganics11030135A New 1D Ni (II) Coordination Polymer of <i>s</i>-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-<i>Bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazineKholood A. Dahlous0Saied M. Soliman1Matti Haukka2Ayman El-Faham3Raghdaa A. Massoud4Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptDepartment of Chemistry, University of Jyväskylä, P.O. Box 35, FI-40014 Jyväskylä, FinlandDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptA new 1D Ni(II) coordination polymer was synthesized by the reaction of NiSO<sub>4</sub>·6H<sub>2</sub>O with 2,4-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPT) and SCN<sup>−</sup> as a linker in an acidic medium by heating under reflux conditions. Unusually, the BPT ligand underwent acid-mediated hydrolysis by losing one of the pyrazolyl arms afforded the polymeric [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex (MPT: 4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazin-2-ol. The Ni(II) center is coordinated with one MPT as a bidentate <i>NN</i>-chelate, one water molecule, and two thiocyanate groups in <i>cis</i> positions to one another. One of the thiocyanate groups acts as a bridging ligand between metal centers, leading to a one-dimensional polymeric structure that extends along the <i>c</i>-direction. The other thiocyanate group is terminally N-coordinated. The [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex has been screened in vitro against two pathogenic fungal strains: <i>A. fumigatus</i>, <i>C. albican</i>, and four pathogenic bacterial strains: <i>S. aureus</i>, <i>B. subtilis</i> as gram-positive bacteria, <i>E. coli</i>, <i>P. vulgaris</i> as gram-negative bacteria. The results showed that the complex has the potential to be used as both an antibacterial and an antifungal agent. Also, the [Ni(MPT)(H<sub>2</sub>O)(SCN)<sub>2</sub>]<sub>n</sub> complex showed cytotoxic activities against hepatocellular (HepG-2) and lung (A-549) cell lines, with IC<sub>50</sub> values of 132.67 ± 5.14 and 146.97 ± 7.34 μM, respectively.https://www.mdpi.com/2304-6740/11/3/135nickel (II)s-triazineantimicrobialcytotoxicityliver and lung carcinomas |
| spellingShingle | Kholood A. Dahlous Saied M. Soliman Matti Haukka Ayman El-Faham Raghdaa A. Massoud A New 1D Ni (II) Coordination Polymer of <i>s</i>-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-<i>Bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine Inorganics nickel (II) s-triazine antimicrobial cytotoxicity liver and lung carcinomas |
| title | A New 1D Ni (II) Coordination Polymer of <i>s</i>-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-<i>Bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine |
| title_full | A New 1D Ni (II) Coordination Polymer of <i>s</i>-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-<i>Bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine |
| title_fullStr | A New 1D Ni (II) Coordination Polymer of <i>s</i>-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-<i>Bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine |
| title_full_unstemmed | A New 1D Ni (II) Coordination Polymer of <i>s</i>-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-<i>Bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine |
| title_short | A New 1D Ni (II) Coordination Polymer of <i>s</i>-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-<i>Bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine |
| title_sort | new 1d ni ii coordination polymer of i s i triazine type ligand and thiocyanate as linker via unexpected hydrolysis of 2 4 i bis i 3 5 dimethyl 1 i h i pyrazol 1 yl 6 methoxy 1 3 5 triazine |
| topic | nickel (II) s-triazine antimicrobial cytotoxicity liver and lung carcinomas |
| url | https://www.mdpi.com/2304-6740/11/3/135 |
| work_keys_str_mv | AT kholoodadahlous anew1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT saiedmsoliman anew1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT mattihaukka anew1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT aymanelfaham anew1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT raghdaaamassoud anew1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT kholoodadahlous new1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT saiedmsoliman new1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT mattihaukka new1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT aymanelfaham new1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine AT raghdaaamassoud new1dniiicoordinationpolymerofisitriazinetypeligandandthiocyanateaslinkerviaunexpectedhydrolysisof24ibisi35dimethyl1ihipyrazol1yl6methoxy135triazine |