Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study
Abstract Background There is evidence indicating that pesticide exposure is a risk factor for non-Hodgkin lymphoma (NHL) development. However, the association between pesticide exposure and NHL survival is not well-established. Methods Using the California Cancer Registry, we identified patients wit...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12916-022-02348-7 |
| _version_ | 1828370765758595072 |
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| author | Christina Poh John D. McPherson Joseph Tuscano Qian Li Arti Parikh-Patel Christoph F. A. Vogel Myles Cockburn Theresa Keegan |
| author_facet | Christina Poh John D. McPherson Joseph Tuscano Qian Li Arti Parikh-Patel Christoph F. A. Vogel Myles Cockburn Theresa Keegan |
| author_sort | Christina Poh |
| collection | DOAJ |
| description | Abstract Background There is evidence indicating that pesticide exposure is a risk factor for non-Hodgkin lymphoma (NHL) development. However, the association between pesticide exposure and NHL survival is not well-established. Methods Using the California Cancer Registry, we identified patients with a first primary diagnosis of NHL from 2010 to 2016 and linked these patients with CalEnviroScreen 3.0 to obtain production agriculture pesticide exposure to 70 chemicals from the state-mandated Pesticide Use Reporting (PUR) by census tract from 2012 to 2014. In addition, data from PUR was integrated into a geographic information system that employs land-use data to estimate cumulative exposure to specific pesticides previously associated with NHL (glyphosate, organophosphorus, carbamate, phenoxyherbicide, and 2,4-dimethylamine salt) between 10 years prior up to 1 year after NHL diagnosis. Multivariable Cox proportional hazards regression models were used to evaluate the association between total pesticide exposure from CalEnviroScreen 3.0 and individual pesticide exposure from geographic land use data and lymphoma-specific and overall survival. Results Among 35,808 NHL patients identified, 44.2% were exposed to pesticide in their census tract of residence. Glyphosate, organophosphorus, carbamate, phenoxyherbicide, and 2,4-dimethylamine salt exposure was observed in 34.1%, 26.0%, 10.6%, 14.0%, and 12.8% of NHL patients, respectively. Total pesticide exposure at the time of diagnosis was not associated with lymphoma-specific or overall survival. In addition, no association was consistently found between glyphosate, organophosphorus, carbamate, phenoxyherbicide, and 2,4 dimethylamine salt exposure and lymphoma-specific or overall survival. Conclusions Although we found no consistent associations between agricultural pesticide exposure at the neighborhood level and worse survival, these results provide a platform for designing future studies to determine the association between pesticide and NHL. |
| first_indexed | 2024-04-14T06:42:29Z |
| format | Article |
| id | doaj.art-ec3ef03438e24905b763701143231a12 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-04-14T06:42:29Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-ec3ef03438e24905b763701143231a122022-12-22T02:07:18ZengBMCBMC Medicine1741-70152022-04-0120111210.1186/s12916-022-02348-7Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based studyChristina Poh0John D. McPherson1Joseph Tuscano2Qian Li3Arti Parikh-Patel4Christoph F. A. Vogel5Myles Cockburn6Theresa Keegan7Division of Medical Oncology, University of WashingtonDivision of Hematology/Oncology, UC Davis Comprehensive Cancer CenterDivision of Hematology/Oncology, UC Davis Comprehensive Cancer CenterDivision of Hematology/Oncology, UC Davis Comprehensive Cancer CenterCalifornia Cancer Reporting and Epidemiologic Surveillance Program, UC DavisDepartment of Environmental Toxicology and the Center for Health and the Environment, UC DavisDepartment of Preventive Medicine, Keck School of Medicine, University of Southern CaliforniaDivision of Hematology/Oncology, UC Davis Comprehensive Cancer CenterAbstract Background There is evidence indicating that pesticide exposure is a risk factor for non-Hodgkin lymphoma (NHL) development. However, the association between pesticide exposure and NHL survival is not well-established. Methods Using the California Cancer Registry, we identified patients with a first primary diagnosis of NHL from 2010 to 2016 and linked these patients with CalEnviroScreen 3.0 to obtain production agriculture pesticide exposure to 70 chemicals from the state-mandated Pesticide Use Reporting (PUR) by census tract from 2012 to 2014. In addition, data from PUR was integrated into a geographic information system that employs land-use data to estimate cumulative exposure to specific pesticides previously associated with NHL (glyphosate, organophosphorus, carbamate, phenoxyherbicide, and 2,4-dimethylamine salt) between 10 years prior up to 1 year after NHL diagnosis. Multivariable Cox proportional hazards regression models were used to evaluate the association between total pesticide exposure from CalEnviroScreen 3.0 and individual pesticide exposure from geographic land use data and lymphoma-specific and overall survival. Results Among 35,808 NHL patients identified, 44.2% were exposed to pesticide in their census tract of residence. Glyphosate, organophosphorus, carbamate, phenoxyherbicide, and 2,4-dimethylamine salt exposure was observed in 34.1%, 26.0%, 10.6%, 14.0%, and 12.8% of NHL patients, respectively. Total pesticide exposure at the time of diagnosis was not associated with lymphoma-specific or overall survival. In addition, no association was consistently found between glyphosate, organophosphorus, carbamate, phenoxyherbicide, and 2,4 dimethylamine salt exposure and lymphoma-specific or overall survival. Conclusions Although we found no consistent associations between agricultural pesticide exposure at the neighborhood level and worse survival, these results provide a platform for designing future studies to determine the association between pesticide and NHL.https://doi.org/10.1186/s12916-022-02348-7PesticideLymphomaSurvival |
| spellingShingle | Christina Poh John D. McPherson Joseph Tuscano Qian Li Arti Parikh-Patel Christoph F. A. Vogel Myles Cockburn Theresa Keegan Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study BMC Medicine Pesticide Lymphoma Survival |
| title | Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study |
| title_full | Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study |
| title_fullStr | Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study |
| title_full_unstemmed | Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study |
| title_short | Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study |
| title_sort | environmental pesticide exposure and non hodgkin lymphoma survival a population based study |
| topic | Pesticide Lymphoma Survival |
| url | https://doi.org/10.1186/s12916-022-02348-7 |
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