A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
Therapies and vaccines for COVID-19, caused by the SARS-CoV-2 viral pandemic, are urgently needed. Here the authors establish and screen an antibody library from a convalescent COVID-19 patient to isolate a neutralizing antibody with the ability to reduce viral titer and alleviate symptoms in ferret...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20602-5 |
| _version_ | 1818733775776907264 |
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| author | Cheolmin Kim Dong-Kyun Ryu Jihun Lee Young-Il Kim Ji-Min Seo Yeon-Gil Kim Jae-Hee Jeong Minsoo Kim Jong-In Kim Pankyeom Kim Jin Soo Bae Eun Yeong Shim Min Seob Lee Man Su Kim Hanmi Noh Geun-Soo Park Jae Sang Park Dain Son Yongjin An Jeong No Lee Ki-Sung Kwon Joo-Yeon Lee Hansaem Lee Jeong-Sun Yang Kyung-Chang Kim Sung Soon Kim Hye-Min Woo Jun-Won Kim Man-Seong Park Kwang-Min Yu Se-Mi Kim Eun-Ha Kim Su-Jin Park Seong Tae Jeong Chi Ho Yu Youngjo Song Se Hun Gu Hanseul Oh Bon-Sang Koo Jung Joo Hong Choong-Min Ryu Wan Beom Park Myoung-don Oh Young Ki Choi Soo-Young Lee |
| author_facet | Cheolmin Kim Dong-Kyun Ryu Jihun Lee Young-Il Kim Ji-Min Seo Yeon-Gil Kim Jae-Hee Jeong Minsoo Kim Jong-In Kim Pankyeom Kim Jin Soo Bae Eun Yeong Shim Min Seob Lee Man Su Kim Hanmi Noh Geun-Soo Park Jae Sang Park Dain Son Yongjin An Jeong No Lee Ki-Sung Kwon Joo-Yeon Lee Hansaem Lee Jeong-Sun Yang Kyung-Chang Kim Sung Soon Kim Hye-Min Woo Jun-Won Kim Man-Seong Park Kwang-Min Yu Se-Mi Kim Eun-Ha Kim Su-Jin Park Seong Tae Jeong Chi Ho Yu Youngjo Song Se Hun Gu Hanseul Oh Bon-Sang Koo Jung Joo Hong Choong-Min Ryu Wan Beom Park Myoung-don Oh Young Ki Choi Soo-Young Lee |
| author_sort | Cheolmin Kim |
| collection | DOAJ |
| description | Therapies and vaccines for COVID-19, caused by the SARS-CoV-2 viral pandemic, are urgently needed. Here the authors establish and screen an antibody library from a convalescent COVID-19 patient to isolate a neutralizing antibody with the ability to reduce viral titer and alleviate symptoms in ferret, hamster, and rhesus monkey infection models. |
| first_indexed | 2024-12-17T23:54:50Z |
| format | Article |
| id | doaj.art-ec3f24e9305e4570b111ea9285c26144 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T23:54:50Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ec3f24e9305e4570b111ea9285c261442022-12-21T21:28:06ZengNature PortfolioNature Communications2041-17232021-01-0112111010.1038/s41467-020-20602-5A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike proteinCheolmin Kim0Dong-Kyun Ryu1Jihun Lee2Young-Il Kim3Ji-Min Seo4Yeon-Gil Kim5Jae-Hee Jeong6Minsoo Kim7Jong-In Kim8Pankyeom Kim9Jin Soo Bae10Eun Yeong Shim11Min Seob Lee12Man Su Kim13Hanmi Noh14Geun-Soo Park15Jae Sang Park16Dain Son17Yongjin An18Jeong No Lee19Ki-Sung Kwon20Joo-Yeon Lee21Hansaem Lee22Jeong-Sun Yang23Kyung-Chang Kim24Sung Soon Kim25Hye-Min Woo26Jun-Won Kim27Man-Seong Park28Kwang-Min Yu29Se-Mi Kim30Eun-Ha Kim31Su-Jin Park32Seong Tae Jeong33Chi Ho Yu34Youngjo Song35Se Hun Gu36Hanseul Oh37Bon-Sang Koo38Jung Joo Hong39Choong-Min Ryu40Wan Beom Park41Myoung-don Oh42Young Ki Choi43Soo-Young Lee44Biotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncCollege of Medicine and Medical Research Institute, Chungbuk National UniversityBiotechnology Research Institute, Celltrion IncPohang Accelerator Laboratory, Pohang University of Science and TechnologyPohang Accelerator Laboratory, Pohang University of Science and TechnologyBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncBiotechnology Research Institute, Celltrion IncCenter for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and PreventionCenter for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and PreventionCenter for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and PreventionCenter for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and PreventionCenter for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and PreventionCenter for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and PreventionCenter for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and PreventionDepartment of Microbiology and Institute for Viral Diseases, College of Medicine, Korea UniversityCollege of Medicine and Medical Research Institute, Chungbuk National UniversityCollege of Medicine and Medical Research Institute, Chungbuk National UniversityCollege of Medicine and Medical Research Institute, Chungbuk National UniversityCollege of Medicine and Medical Research Institute, Chungbuk National UniversityThe 4th R&D Institute, Agency for Defense DevelopmentThe 4th R&D Institute, Agency for Defense DevelopmentThe 4th R&D Institute, Agency for Defense DevelopmentThe 4th R&D Institute, Agency for Defense DevelopmentNational Primate Research Centre, Korea Research Institute of Bioscience and BiotechnologyNational Primate Research Centre, Korea Research Institute of Bioscience and BiotechnologyNational Primate Research Centre, Korea Research Institute of Bioscience and BiotechnologyInfectious Disease Research Centre, Korea Research Institute of Bioscience and BiotechnologyDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineCollege of Medicine and Medical Research Institute, Chungbuk National UniversityBiotechnology Research Institute, Celltrion IncTherapies and vaccines for COVID-19, caused by the SARS-CoV-2 viral pandemic, are urgently needed. Here the authors establish and screen an antibody library from a convalescent COVID-19 patient to isolate a neutralizing antibody with the ability to reduce viral titer and alleviate symptoms in ferret, hamster, and rhesus monkey infection models.https://doi.org/10.1038/s41467-020-20602-5 |
| spellingShingle | Cheolmin Kim Dong-Kyun Ryu Jihun Lee Young-Il Kim Ji-Min Seo Yeon-Gil Kim Jae-Hee Jeong Minsoo Kim Jong-In Kim Pankyeom Kim Jin Soo Bae Eun Yeong Shim Min Seob Lee Man Su Kim Hanmi Noh Geun-Soo Park Jae Sang Park Dain Son Yongjin An Jeong No Lee Ki-Sung Kwon Joo-Yeon Lee Hansaem Lee Jeong-Sun Yang Kyung-Chang Kim Sung Soon Kim Hye-Min Woo Jun-Won Kim Man-Seong Park Kwang-Min Yu Se-Mi Kim Eun-Ha Kim Su-Jin Park Seong Tae Jeong Chi Ho Yu Youngjo Song Se Hun Gu Hanseul Oh Bon-Sang Koo Jung Joo Hong Choong-Min Ryu Wan Beom Park Myoung-don Oh Young Ki Choi Soo-Young Lee A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein Nature Communications |
| title | A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein |
| title_full | A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein |
| title_fullStr | A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein |
| title_full_unstemmed | A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein |
| title_short | A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein |
| title_sort | therapeutic neutralizing antibody targeting receptor binding domain of sars cov 2 spike protein |
| url | https://doi.org/10.1038/s41467-020-20602-5 |
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