A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells
MicroRNAs (miRNAs) are small noncoding RNAs that regulate a variety of physiological and pathological functions. miR-26a is one of the many miRNAs that have been identified as regulators of cancer development and as potential anticancer drug targets. However, the specific cellular and molecular mech...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253122002359 |
| _version_ | 1798003232559071232 |
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| author | Yan Tian Mingfeng Zhang Mingjie Fan Haixia Xu Shunquan Wu Sailan Zou Yangmeng Wang Dongmei Tang Chunyan Zhang Weidong Han Hua Yu Xianghui Fu Wendong Huang |
| author_facet | Yan Tian Mingfeng Zhang Mingjie Fan Haixia Xu Shunquan Wu Sailan Zou Yangmeng Wang Dongmei Tang Chunyan Zhang Weidong Han Hua Yu Xianghui Fu Wendong Huang |
| author_sort | Yan Tian |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are small noncoding RNAs that regulate a variety of physiological and pathological functions. miR-26a is one of the many miRNAs that have been identified as regulators of cancer development and as potential anticancer drug targets. However, the specific cellular and molecular mechanisms by which miR-26a attenuates hepatocarcinogenesis are still elusive. Here, we interrogated mouse models with miR-26a cell-specific overexpression in either hepatocytes or myeloid cells to show that miR-26a strongly attenuated the chemical-induced hepatocellular carcinoma (HCC). miR-26a overexpression broadly inhibited the inflammatory response in both hepatocytes and macrophages by decreasing several key oncogenic signaling pathways in HCC promotion. These findings thus reveal new insights into a concerted role of miR-26a in both hepatocytes and Kupffer cells to suppress hepatocarcinogenesis, thereby highlighting the potential use of miR-26a mimetics as potential approaches for the prevention and treatment of HCC. |
| first_indexed | 2024-04-11T12:04:36Z |
| format | Article |
| id | doaj.art-ec3f9e2e88a346e193db0d00c6b7d5fe |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-04-11T12:04:36Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-ec3f9e2e88a346e193db0d00c6b7d5fe2022-12-22T04:24:46ZengElsevierMolecular Therapy: Nucleic Acids2162-25312022-12-0130112A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cellsYan Tian0Mingfeng Zhang1Mingjie Fan2Haixia Xu3Shunquan Wu4Sailan Zou5Yangmeng Wang6Dongmei Tang7Chunyan Zhang8Weidong Han9Hua Yu10Xianghui Fu11Wendong Huang12Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China; Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USADepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USADepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USADivision of Endocrinology and Metabolism, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, ChinaDepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USADivision of Endocrinology and Metabolism, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, ChinaDepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USADivision of Endocrinology and Metabolism, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, ChinaDepartment of Immuno-oncology, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USADepartment of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA; Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, Zhejiang 310016, ChinaDepartment of Immuno-oncology, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA; Graduate School of Biological Science, City of Hope National Medical Center, Duarte, CA 91010, USADivision of Endocrinology and Metabolism, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China; Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA; Corresponding author Xianghui Fu, Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA; Graduate School of Biological Science, City of Hope National Medical Center, Duarte, CA 91010, USA; Corresponding author Wendong Huang, PhD, Department of Diabetes Complications and Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA.MicroRNAs (miRNAs) are small noncoding RNAs that regulate a variety of physiological and pathological functions. miR-26a is one of the many miRNAs that have been identified as regulators of cancer development and as potential anticancer drug targets. However, the specific cellular and molecular mechanisms by which miR-26a attenuates hepatocarcinogenesis are still elusive. Here, we interrogated mouse models with miR-26a cell-specific overexpression in either hepatocytes or myeloid cells to show that miR-26a strongly attenuated the chemical-induced hepatocellular carcinoma (HCC). miR-26a overexpression broadly inhibited the inflammatory response in both hepatocytes and macrophages by decreasing several key oncogenic signaling pathways in HCC promotion. These findings thus reveal new insights into a concerted role of miR-26a in both hepatocytes and Kupffer cells to suppress hepatocarcinogenesis, thereby highlighting the potential use of miR-26a mimetics as potential approaches for the prevention and treatment of HCC.http://www.sciencedirect.com/science/article/pii/S2162253122002359 |
| spellingShingle | Yan Tian Mingfeng Zhang Mingjie Fan Haixia Xu Shunquan Wu Sailan Zou Yangmeng Wang Dongmei Tang Chunyan Zhang Weidong Han Hua Yu Xianghui Fu Wendong Huang A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells Molecular Therapy: Nucleic Acids |
| title | A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells |
| title_full | A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells |
| title_fullStr | A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells |
| title_full_unstemmed | A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells |
| title_short | A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells |
| title_sort | mirna mediated attenuation of hepatocarcinogenesis in both hepatocytes and kupffer cells |
| url | http://www.sciencedirect.com/science/article/pii/S2162253122002359 |
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