System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation

System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation

Germinal center (GC) reactions are vital to the correct functioning of the adaptive immune system, through formation of high affinity, class switched antibodies. GCs are transient anatomical structures in secondary lymphoid organs where specific B cells, after recognition of antigen and with T cell...

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Bibliographic Details
Main Authors: Niels J. M. Verstegen, Victor Ubels, Hans V. Westerhoff, S. Marieke van Ham, Matteo Barberis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
systems biology
T follicular helper cells
B cells
mathematical modeling
B cell recycling and differentiation
memory B cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.734282/full

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