A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study

A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study

Summary: Background: Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines. We d...

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Main Authors: Joshua Osowicki, MBBS, Kristy I Azzopardi, BSc, Loraine Fabri, MD, Hannah R Frost, PhD, Tania Rivera-Hernandez, PhD, Melanie R Neeland, PhD, Alana L Whitcombe, BSc, Anneke Grobler, PhD, Sarah J Gutman, MBBS, Ciara Baker, MSc, Janet M F Wong, MBBS, Jason D Lickliter, PhD, Claire S Waddington, PhD, Manisha Pandey, PhD, Tibor Schuster, PhD, Allen C Cheng, ProfPhD, Andrew J Pollard, ProfPhD, James S McCarthy, ProfMD, Michael F Good, ProfPhD, James B Dale, ProfMD, Michael Batzloff, PhD, Nicole J Moreland, PhD, Mark J Walker, ProfPhD, Jonathan R Carapetis, ProfPhD, Pierre R Smeesters, ProfPhD, Andrew C Steer, ProfPhD
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:The Lancet Microbe
Online Access:http://www.sciencedirect.com/science/article/pii/S2666524720302408

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