The Human Pathogen Paracoccidioides brasiliensis Has a Unique 1-Cys Peroxiredoxin That Localizes Both Intracellularly and at the Cell Surface

The Human Pathogen Paracoccidioides brasiliensis Has a Unique 1-Cys Peroxiredoxin That Localizes Both Intracellularly and at the Cell Surface

Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus that causes systemic paracoccidioidomycosis, a granulomatous disease. The massive production of reactive oxygen species (ROS) by the host's cellular immune response is an essential strategy to restrain the fungal growth....

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Bibliographic Details
Main Authors: Larissa Valle Guilhen Longo, Carlos Alexandre Breyer, Gabriela Machado Novaes, Gregory Gegembauer, Natanael Pinheiro Leitão, Carla Elizabete Octaviano, Marcos Hikari Toyama, Marcos Antonio de Oliveira, Rosana Puccia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Paracoccidioides brasiliensis
1-Cys Prx
hydroperoxides
peroxiredoxin
dimorphic fungi
ROS
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00394/full

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