Nuclear Functions of TOR: Impact on Transcription and the Epigenome
The target of rapamycin (TOR) protein kinase is at the core of growth factor- and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stabil...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/11/6/641 |
| _version_ | 1797565683174735872 |
|---|---|
| author | R. Nicholas Laribee Ronit Weisman |
| author_facet | R. Nicholas Laribee Ronit Weisman |
| author_sort | R. Nicholas Laribee |
| collection | DOAJ |
| description | The target of rapamycin (TOR) protein kinase is at the core of growth factor- and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through active nuclear TOR pools. The mechanisms by which TOR regulates its nuclear functions are less well-understood compared with its cytoplasmic activities. TOR is an important pharmacological target for several diseases, including cancer, metabolic and neurological disorders. Thus, studies of the nuclear functions of TOR are important for our understanding of basic biological processes, as well as for clinical implications. |
| first_indexed | 2024-03-10T19:16:30Z |
| format | Article |
| id | doaj.art-ec4363c0860948d3939b4d1bfe738054 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T19:16:30Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ec4363c0860948d3939b4d1bfe7380542023-11-20T03:25:46ZengMDPI AGGenes2073-44252020-06-0111664110.3390/genes11060641Nuclear Functions of TOR: Impact on Transcription and the EpigenomeR. Nicholas Laribee0Ronit Weisman1Department of Pathology and Laboratory Medicine, College of Medicine and Center for Cancer Research, University of Tennessee Health Science Center, 19 South Manassas, Cancer Research Building Rm 318, Memphis, TN 38163, USADepartment of Natural and Life Sciences, The Open University of Israel, University Road 1, Ra’anana 4353701, IsraelThe target of rapamycin (TOR) protein kinase is at the core of growth factor- and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through active nuclear TOR pools. The mechanisms by which TOR regulates its nuclear functions are less well-understood compared with its cytoplasmic activities. TOR is an important pharmacological target for several diseases, including cancer, metabolic and neurological disorders. Thus, studies of the nuclear functions of TOR are important for our understanding of basic biological processes, as well as for clinical implications.https://www.mdpi.com/2073-4425/11/6/641target of rapamycinTORC1TORC2epigeneticshistonesacetylation |
| spellingShingle | R. Nicholas Laribee Ronit Weisman Nuclear Functions of TOR: Impact on Transcription and the Epigenome Genes target of rapamycin TORC1 TORC2 epigenetics histones acetylation |
| title | Nuclear Functions of TOR: Impact on Transcription and the Epigenome |
| title_full | Nuclear Functions of TOR: Impact on Transcription and the Epigenome |
| title_fullStr | Nuclear Functions of TOR: Impact on Transcription and the Epigenome |
| title_full_unstemmed | Nuclear Functions of TOR: Impact on Transcription and the Epigenome |
| title_short | Nuclear Functions of TOR: Impact on Transcription and the Epigenome |
| title_sort | nuclear functions of tor impact on transcription and the epigenome |
| topic | target of rapamycin TORC1 TORC2 epigenetics histones acetylation |
| url | https://www.mdpi.com/2073-4425/11/6/641 |
| work_keys_str_mv | AT rnicholaslaribee nuclearfunctionsoftorimpactontranscriptionandtheepigenome AT ronitweisman nuclearfunctionsoftorimpactontranscriptionandtheepigenome |