IFN-γ-INDUCED PROTEIN 10 (IP-10) IN RHEUMATOID ARTHRITIS: LITERATURE REVIEW AND THE AUTHORS' OWN DATA
Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease characterized by chronic inflammation of joint synovial membrane and progressive destruction of bone and cartilage. Massive synovial infiltration with immune and inflammatory cells, such as macrophages, monocytes, granulocytes,...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2018-01-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2471 |
| _version_ | 1826556041297395712 |
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| author | A. S. Avdeeva |
| author_facet | A. S. Avdeeva |
| author_sort | A. S. Avdeeva |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease characterized by chronic inflammation of joint synovial membrane and progressive destruction of bone and cartilage. Massive synovial infiltration with immune and inflammatory cells, such as macrophages, monocytes, granulocytes, plasma cells and dendritic cells, B lymphocytes, CD4+ and CD8+ T lymphocytes, presented mainly by effector T cells (Teff), underlies chronic inflammation and joint destruction in RA. C-X-C-chemokine 10 (CXCL10) was originally identified as a chemokine secreted by several types of cells: macrophages, endothelial cells, and fibroblasts in response to the production of interferon-γ (IFN-γ). It is also known as IFN-γ- induced protein 10 (IP-10). It has been recently discovered that the level of CXCL10 is elevated in the serum and joint tissues of laboratory animals with collagen-induced arthritis. Patients with RA demonstrated higher serum, synovial fluid, and synovial tissue levels of IP-10 than those with osteoarthritis or healthy donors at both early and late stages of the disease. Peripheral blood IP-10, unlike acute-phase measures or indices of activity, may more accurately reflect remission status, which should be kept in mind while deciding for therapy optimization. IP-10 may be a marker for more severe disease and can be used to assess the risk of psoriatic arthritis in patients with psoriasis; its prognostic value in patients with probable RA requires further clarification. Elevated IP-10 levels may be associated with the development of interstitial lung disease in patients with RA and identified in asymptomatic early-stage patients. Thus, IP-10 may be a useful and promising prognostic marker in RA, the significance of which requires further investigation. |
| first_indexed | 2024-04-09T22:24:39Z |
| format | Article |
| id | doaj.art-ec4636bbf92040aeb033ca42f010ed30 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2025-03-14T08:06:24Z |
| publishDate | 2018-01-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-ec4636bbf92040aeb033ca42f010ed302025-03-02T13:23:44ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922018-01-0155665566110.14412/1995-4484-2017-655-6612292IFN-γ-INDUCED PROTEIN 10 (IP-10) IN RHEUMATOID ARTHRITIS: LITERATURE REVIEW AND THE AUTHORS' OWN DATAA. S. Avdeeva0V.A. Nasonova Research Institute of Rheumatology, MoscowRheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease characterized by chronic inflammation of joint synovial membrane and progressive destruction of bone and cartilage. Massive synovial infiltration with immune and inflammatory cells, such as macrophages, monocytes, granulocytes, plasma cells and dendritic cells, B lymphocytes, CD4+ and CD8+ T lymphocytes, presented mainly by effector T cells (Teff), underlies chronic inflammation and joint destruction in RA. C-X-C-chemokine 10 (CXCL10) was originally identified as a chemokine secreted by several types of cells: macrophages, endothelial cells, and fibroblasts in response to the production of interferon-γ (IFN-γ). It is also known as IFN-γ- induced protein 10 (IP-10). It has been recently discovered that the level of CXCL10 is elevated in the serum and joint tissues of laboratory animals with collagen-induced arthritis. Patients with RA demonstrated higher serum, synovial fluid, and synovial tissue levels of IP-10 than those with osteoarthritis or healthy donors at both early and late stages of the disease. Peripheral blood IP-10, unlike acute-phase measures or indices of activity, may more accurately reflect remission status, which should be kept in mind while deciding for therapy optimization. IP-10 may be a marker for more severe disease and can be used to assess the risk of psoriatic arthritis in patients with psoriasis; its prognostic value in patients with probable RA requires further clarification. Elevated IP-10 levels may be associated with the development of interstitial lung disease in patients with RA and identified in asymptomatic early-stage patients. Thus, IP-10 may be a useful and promising prognostic marker in RA, the significance of which requires further investigation.https://rsp.mediar-press.net/rsp/article/view/2471rheumatoid arthritisdisease activityc-x-c chemokinesifn-γ-induced protein 10effectiveness of therapybiomarkers |
| spellingShingle | A. S. Avdeeva IFN-γ-INDUCED PROTEIN 10 (IP-10) IN RHEUMATOID ARTHRITIS: LITERATURE REVIEW AND THE AUTHORS' OWN DATA Научно-практическая ревматология rheumatoid arthritis disease activity c-x-c chemokines ifn-γ-induced protein 10 effectiveness of therapy biomarkers |
| title | IFN-γ-INDUCED PROTEIN 10 (IP-10) IN RHEUMATOID ARTHRITIS: LITERATURE REVIEW AND THE AUTHORS' OWN DATA |
| title_full | IFN-γ-INDUCED PROTEIN 10 (IP-10) IN RHEUMATOID ARTHRITIS: LITERATURE REVIEW AND THE AUTHORS' OWN DATA |
| title_fullStr | IFN-γ-INDUCED PROTEIN 10 (IP-10) IN RHEUMATOID ARTHRITIS: LITERATURE REVIEW AND THE AUTHORS' OWN DATA |
| title_full_unstemmed | IFN-γ-INDUCED PROTEIN 10 (IP-10) IN RHEUMATOID ARTHRITIS: LITERATURE REVIEW AND THE AUTHORS' OWN DATA |
| title_short | IFN-γ-INDUCED PROTEIN 10 (IP-10) IN RHEUMATOID ARTHRITIS: LITERATURE REVIEW AND THE AUTHORS' OWN DATA |
| title_sort | ifn γ induced protein 10 ip 10 in rheumatoid arthritis literature review and the authors own data |
| topic | rheumatoid arthritis disease activity c-x-c chemokines ifn-γ-induced protein 10 effectiveness of therapy biomarkers |
| url | https://rsp.mediar-press.net/rsp/article/view/2471 |
| work_keys_str_mv | AT asavdeeva ifnginducedprotein10ip10inrheumatoidarthritisliteraturereviewandtheauthorsowndata |