Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer
Tuberculosis and lung cancer are, in many cases, correlated diseases that can be confused because they have similar symptoms. Many meta-analyses have proven that there is a greater chance of developing lung cancer in patients who have active pulmonary tuberculosis. It is, therefore, important to mon...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1183247/full |
| _version_ | 1827932798798790656 |
|---|---|
| author | Giulia Polinário Laura Maria Duran Gleriani Primo Maiara Alane Baraldi Cerquetani Rosa Freddy Humberto Marin Dett Paula Aboud Barbugli Cesar Augusto Roque-Borda Fernando Rogério Pavan |
| author_facet | Giulia Polinário Laura Maria Duran Gleriani Primo Maiara Alane Baraldi Cerquetani Rosa Freddy Humberto Marin Dett Paula Aboud Barbugli Cesar Augusto Roque-Borda Fernando Rogério Pavan |
| author_sort | Giulia Polinário |
| collection | DOAJ |
| description | Tuberculosis and lung cancer are, in many cases, correlated diseases that can be confused because they have similar symptoms. Many meta-analyses have proven that there is a greater chance of developing lung cancer in patients who have active pulmonary tuberculosis. It is, therefore, important to monitor the patient for a long time after recovery and search for combined therapies that can treat both diseases, as well as face the great problem of drug resistance. Peptides are molecules derived from the breakdown of proteins, and the membranolytic class is already being studied. It has been proposed that these molecules destabilize cellular homeostasis, performing a dual antimicrobial and anticancer function and offering several possibilities of adaptation for adequate delivery and action. In this review, we focus on two important reason for the use of multifunctional peptides or peptides, namely the double activity and no harmful effects on humans. We review some of the main antimicrobial and anti-inflammatory bioactive peptides and highlight four that have anti-tuberculosis and anti-cancer activity, which may contribute to obtaining drugs with this dual functionality. |
| first_indexed | 2024-03-13T07:15:32Z |
| format | Article |
| id | doaj.art-ec466330eace4bddaf60b7c0f7f1b9e9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-13T07:15:32Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ec466330eace4bddaf60b7c0f7f1b9e92023-06-05T09:26:51ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-06-011410.3389/fmicb.2023.11832471183247Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancerGiulia Polinário0Laura Maria Duran Gleriani Primo1Maiara Alane Baraldi Cerquetani Rosa2Freddy Humberto Marin Dett3Paula Aboud Barbugli4Cesar Augusto Roque-Borda5Fernando Rogério Pavan6School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilVicerrectorado de Investigación, Universidad Católica de Santa María (UCSM), Arequipa, PeruSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilTuberculosis and lung cancer are, in many cases, correlated diseases that can be confused because they have similar symptoms. Many meta-analyses have proven that there is a greater chance of developing lung cancer in patients who have active pulmonary tuberculosis. It is, therefore, important to monitor the patient for a long time after recovery and search for combined therapies that can treat both diseases, as well as face the great problem of drug resistance. Peptides are molecules derived from the breakdown of proteins, and the membranolytic class is already being studied. It has been proposed that these molecules destabilize cellular homeostasis, performing a dual antimicrobial and anticancer function and offering several possibilities of adaptation for adequate delivery and action. In this review, we focus on two important reason for the use of multifunctional peptides or peptides, namely the double activity and no harmful effects on humans. We review some of the main antimicrobial and anti-inflammatory bioactive peptides and highlight four that have anti-tuberculosis and anti-cancer activity, which may contribute to obtaining drugs with this dual functionality.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1183247/fullMycobacterium tuberculosislung cancerpeptidesmultifunctional peptidestreatment |
| spellingShingle | Giulia Polinário Laura Maria Duran Gleriani Primo Maiara Alane Baraldi Cerquetani Rosa Freddy Humberto Marin Dett Paula Aboud Barbugli Cesar Augusto Roque-Borda Fernando Rogério Pavan Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer Frontiers in Microbiology Mycobacterium tuberculosis lung cancer peptides multifunctional peptides treatment |
| title | Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer |
| title_full | Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer |
| title_fullStr | Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer |
| title_full_unstemmed | Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer |
| title_short | Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer |
| title_sort | antimicrobial peptides as drugs with double response against mycobacterium tuberculosis coinfections in lung cancer |
| topic | Mycobacterium tuberculosis lung cancer peptides multifunctional peptides treatment |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1183247/full |
| work_keys_str_mv | AT giuliapolinario antimicrobialpeptidesasdrugswithdoubleresponseagainstmycobacteriumtuberculosiscoinfectionsinlungcancer AT lauramariaduranglerianiprimo antimicrobialpeptidesasdrugswithdoubleresponseagainstmycobacteriumtuberculosiscoinfectionsinlungcancer AT maiaraalanebaraldicerquetanirosa antimicrobialpeptidesasdrugswithdoubleresponseagainstmycobacteriumtuberculosiscoinfectionsinlungcancer AT freddyhumbertomarindett antimicrobialpeptidesasdrugswithdoubleresponseagainstmycobacteriumtuberculosiscoinfectionsinlungcancer AT paulaaboudbarbugli antimicrobialpeptidesasdrugswithdoubleresponseagainstmycobacteriumtuberculosiscoinfectionsinlungcancer AT cesaraugustoroqueborda antimicrobialpeptidesasdrugswithdoubleresponseagainstmycobacteriumtuberculosiscoinfectionsinlungcancer AT fernandorogeriopavan antimicrobialpeptidesasdrugswithdoubleresponseagainstmycobacteriumtuberculosiscoinfectionsinlungcancer |