Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery
Nowadays, infection diseases are one of the most significant threats to humans all around the world. An encouraging strategy for solving this issue and fighting resistant microorganisms is to develop drug carriers for a prolonged release of the antibiotic to the target site. The purpose of this work...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/11/538 |
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| author | Carmen Grierosu Gabriela Calin Daniela Damir Constantin Marcu Radu Cernei Georgeta Zegan Daniela Anistoroaei Mihaela Moscu Elena Mihaela Carausu Letitia Doina Duceac Marius Gabriel Dabija Geta Mitrea Cristian Gutu Elena Roxana Bogdan Goroftei Lucian Eva |
| author_facet | Carmen Grierosu Gabriela Calin Daniela Damir Constantin Marcu Radu Cernei Georgeta Zegan Daniela Anistoroaei Mihaela Moscu Elena Mihaela Carausu Letitia Doina Duceac Marius Gabriel Dabija Geta Mitrea Cristian Gutu Elena Roxana Bogdan Goroftei Lucian Eva |
| author_sort | Carmen Grierosu |
| collection | DOAJ |
| description | Nowadays, infection diseases are one of the most significant threats to humans all around the world. An encouraging strategy for solving this issue and fighting resistant microorganisms is to develop drug carriers for a prolonged release of the antibiotic to the target site. The purpose of this work was to obtain metronidazole-encapsulated chitosan nanoparticles using an ion gelation route and to evaluate their properties. Due to the advantages of the ionic gelation method, the synthesized polymeric nanoparticles can be applied in various fields, especially pharmaceutical and medical. Loading capacity and encapsulation efficiency varFied depending on the amount of antibiotic in each formulation. Physicochemical characterization using scanning electron microscopy revealed a narrow particle size distribution where 90% of chitosan particles were 163.7 nm in size and chitosan-loaded metronidazole nanoparticles were 201.3 nm in size, with a zeta potential value of 36.5 mV. IR spectra revealed characteristic peaks of the drug and polymer nanoparticles. Cell viability assessment revealed that samples have no significant impact on tested cells. Release analysis showed that metronidazole was released from the chitosan matrix for 24 h in a prolonged course, implying that antibiotic-encapsulated polymer nanostructures are a promising drug delivery system to prevent or to treat various diseases. It is desirable to obtain new formulations based on drugs encapsulated in nanoparticles through different preparation methods, with reduced cytotoxic potential, in order to improve the therapeutic effect through sustained and prolonged release mechanisms of the drug correlated with the reduction of adverse effects. |
| first_indexed | 2024-03-09T16:43:30Z |
| format | Article |
| id | doaj.art-ec4791d1d1564e84a8fe902c0602f60f |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:43:30Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-ec4791d1d1564e84a8fe902c0602f60f2023-11-24T14:49:58ZengMDPI AGJournal of Functional Biomaterials2079-49832023-11-01141153810.3390/jfb14110538Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug DeliveryCarmen Grierosu0Gabriela Calin1Daniela Damir2Constantin Marcu3Radu Cernei4Georgeta Zegan5Daniela Anistoroaei6Mihaela Moscu7Elena Mihaela Carausu8Letitia Doina Duceac9Marius Gabriel Dabija10Geta Mitrea11Cristian Gutu12Elena Roxana Bogdan Goroftei13Lucian Eva14Faculty of Dental Medicine, “Apollonia” University of Iasi, 11 Pacurari Str., 700511 Iasi, RomaniaFaculty of Dental Medicine, “Apollonia” University of Iasi, 11 Pacurari Str., 700511 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 Universitatii Str., 700115 Iasi, RomaniaFaculty of Medicine and Pharmacy, University Dunarea de Jos, 47 Domneasca Str., 800008 Galati, RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 Universitatii Str., 700115 Iasi, RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 Universitatii Str., 700115 Iasi, RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 Universitatii Str., 700115 Iasi, RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 Universitatii Str., 700115 Iasi, RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 Universitatii Str., 700115 Iasi, RomaniaFaculty of Dental Medicine, “Apollonia” University of Iasi, 11 Pacurari Str., 700511 Iasi, RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 Universitatii Str., 700115 Iasi, RomaniaFaculty of Medicine and Pharmacy, University Dunarea de Jos, 47 Domneasca Str., 800008 Galati, RomaniaFaculty of Medicine and Pharmacy, University Dunarea de Jos, 47 Domneasca Str., 800008 Galati, RomaniaFaculty of Medicine and Pharmacy, University Dunarea de Jos, 47 Domneasca Str., 800008 Galati, RomaniaFaculty of Dental Medicine, “Apollonia” University of Iasi, 11 Pacurari Str., 700511 Iasi, RomaniaNowadays, infection diseases are one of the most significant threats to humans all around the world. An encouraging strategy for solving this issue and fighting resistant microorganisms is to develop drug carriers for a prolonged release of the antibiotic to the target site. The purpose of this work was to obtain metronidazole-encapsulated chitosan nanoparticles using an ion gelation route and to evaluate their properties. Due to the advantages of the ionic gelation method, the synthesized polymeric nanoparticles can be applied in various fields, especially pharmaceutical and medical. Loading capacity and encapsulation efficiency varFied depending on the amount of antibiotic in each formulation. Physicochemical characterization using scanning electron microscopy revealed a narrow particle size distribution where 90% of chitosan particles were 163.7 nm in size and chitosan-loaded metronidazole nanoparticles were 201.3 nm in size, with a zeta potential value of 36.5 mV. IR spectra revealed characteristic peaks of the drug and polymer nanoparticles. Cell viability assessment revealed that samples have no significant impact on tested cells. Release analysis showed that metronidazole was released from the chitosan matrix for 24 h in a prolonged course, implying that antibiotic-encapsulated polymer nanostructures are a promising drug delivery system to prevent or to treat various diseases. It is desirable to obtain new formulations based on drugs encapsulated in nanoparticles through different preparation methods, with reduced cytotoxic potential, in order to improve the therapeutic effect through sustained and prolonged release mechanisms of the drug correlated with the reduction of adverse effects.https://www.mdpi.com/2079-4983/14/11/538polymer compositebioactivitybiodegradabilitymetronidazolebiomedical application |
| spellingShingle | Carmen Grierosu Gabriela Calin Daniela Damir Constantin Marcu Radu Cernei Georgeta Zegan Daniela Anistoroaei Mihaela Moscu Elena Mihaela Carausu Letitia Doina Duceac Marius Gabriel Dabija Geta Mitrea Cristian Gutu Elena Roxana Bogdan Goroftei Lucian Eva Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery Journal of Functional Biomaterials polymer composite bioactivity biodegradability metronidazole biomedical application |
| title | Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery |
| title_full | Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery |
| title_fullStr | Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery |
| title_full_unstemmed | Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery |
| title_short | Development and Functionalization of a Novel Chitosan-Based Nanosystem for Enhanced Drug Delivery |
| title_sort | development and functionalization of a novel chitosan based nanosystem for enhanced drug delivery |
| topic | polymer composite bioactivity biodegradability metronidazole biomedical application |
| url | https://www.mdpi.com/2079-4983/14/11/538 |
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