Membranous Nephropathy: From Research Bench to Personalized Care
Membranous nephropathy is a glomerulopathy that causes nephrotic syndrome and, in at least a third of cases, lasting end-stage kidney disease (ESKD). It is also a rare case of revolutionary changes in our understanding of the disease, that translates from scientific findings to real diagnosis and tr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/6/1205 |
| _version_ | 1797541434793918464 |
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| author | Barbara Moszczuk Krzysztof Kiryluk Leszek Pączek Krzysztof Mucha |
| author_facet | Barbara Moszczuk Krzysztof Kiryluk Leszek Pączek Krzysztof Mucha |
| author_sort | Barbara Moszczuk |
| collection | DOAJ |
| description | Membranous nephropathy is a glomerulopathy that causes nephrotic syndrome and, in at least a third of cases, lasting end-stage kidney disease (ESKD). It is also a rare case of revolutionary changes in our understanding of the disease, that translates from scientific findings to real diagnosis and treatment recommendations in less than ten years. In this review we present: (1) a short history and traditional approach to patients with membranous nephropathy, (2) current recommendations and treatment options that have emerged in recent years, (3) findings of new studies, with a particular focus on serological/immunological methods, genomic and proteomic studies, still requiring validation. With further development in this field, membranous nephropathy may become one of the first nephrological conditions that apply a truly personalized approach with the omission of invasive measures such as kidney biopsy. |
| first_indexed | 2024-03-10T13:15:58Z |
| format | Article |
| id | doaj.art-ec4da7772c594ea3b6e7398d6d35eb79 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:15:58Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ec4da7772c594ea3b6e7398d6d35eb792023-11-21T10:26:43ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01106120510.3390/jcm10061205Membranous Nephropathy: From Research Bench to Personalized CareBarbara Moszczuk0Krzysztof Kiryluk1Leszek Pączek2Krzysztof Mucha3Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, PolandDepartment of Medicine, Division of Nephrology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USADepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, PolandDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, PolandMembranous nephropathy is a glomerulopathy that causes nephrotic syndrome and, in at least a third of cases, lasting end-stage kidney disease (ESKD). It is also a rare case of revolutionary changes in our understanding of the disease, that translates from scientific findings to real diagnosis and treatment recommendations in less than ten years. In this review we present: (1) a short history and traditional approach to patients with membranous nephropathy, (2) current recommendations and treatment options that have emerged in recent years, (3) findings of new studies, with a particular focus on serological/immunological methods, genomic and proteomic studies, still requiring validation. With further development in this field, membranous nephropathy may become one of the first nephrological conditions that apply a truly personalized approach with the omission of invasive measures such as kidney biopsy.https://www.mdpi.com/2077-0383/10/6/1205membranous nephropathyglomerulonephritispersonalized medicinePLA<sub>2</sub>Rproteomics |
| spellingShingle | Barbara Moszczuk Krzysztof Kiryluk Leszek Pączek Krzysztof Mucha Membranous Nephropathy: From Research Bench to Personalized Care Journal of Clinical Medicine membranous nephropathy glomerulonephritis personalized medicine PLA<sub>2</sub>R proteomics |
| title | Membranous Nephropathy: From Research Bench to Personalized Care |
| title_full | Membranous Nephropathy: From Research Bench to Personalized Care |
| title_fullStr | Membranous Nephropathy: From Research Bench to Personalized Care |
| title_full_unstemmed | Membranous Nephropathy: From Research Bench to Personalized Care |
| title_short | Membranous Nephropathy: From Research Bench to Personalized Care |
| title_sort | membranous nephropathy from research bench to personalized care |
| topic | membranous nephropathy glomerulonephritis personalized medicine PLA<sub>2</sub>R proteomics |
| url | https://www.mdpi.com/2077-0383/10/6/1205 |
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