Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats
Objective: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. Methods: thirty-six Wistar rats, males, ad...
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| Format: | Article |
| Language: | English |
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Colégio Brasileiro de Cirurgiões
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| Series: | Revista do Colégio Brasileiro de Cirurgiões |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000700393&lng=en&tlng=en |
| _version_ | 1818852162010087424 |
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| author | Rosilda Mendes da Silva Osvaldo Malafaia Orlando Jorge Martins Torres Nicolau Gregori Czeczko Carlos Hespanha Marinho Junior Ronaldo Kiviatcoski Kozlowski |
| author_facet | Rosilda Mendes da Silva Osvaldo Malafaia Orlando Jorge Martins Torres Nicolau Gregori Czeczko Carlos Hespanha Marinho Junior Ronaldo Kiviatcoski Kozlowski |
| author_sort | Rosilda Mendes da Silva |
| collection | DOAJ |
| description | Objective: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. Methods: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E. Results: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. Conclusion: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration. |
| first_indexed | 2024-12-19T07:16:32Z |
| format | Article |
| id | doaj.art-ec50182f64044acf8da636d740b276c6 |
| institution | Directory Open Access Journal |
| issn | 1809-4546 |
| language | English |
| last_indexed | 2024-12-19T07:16:32Z |
| publisher | Colégio Brasileiro de Cirurgiões |
| record_format | Article |
| series | Revista do Colégio Brasileiro de Cirurgiões |
| spelling | doaj.art-ec50182f64044acf8da636d740b276c62022-12-21T20:31:04ZengColégio Brasileiro de CirurgiõesRevista do Colégio Brasileiro de Cirurgiões1809-454642639339710.1590/0100-69912015006008S0100-69912015000700393Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in ratsRosilda Mendes da SilvaOsvaldo MalafaiaOrlando Jorge Martins TorresNicolau Gregori CzeczkoCarlos Hespanha Marinho JuniorRonaldo Kiviatcoski KozlowskiObjective: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. Methods: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E. Results: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. Conclusion: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000700393&lng=en&tlng=enHepatectomyLiver RegenerationFatty acidsFatty acids, Omega-3 |
| spellingShingle | Rosilda Mendes da Silva Osvaldo Malafaia Orlando Jorge Martins Torres Nicolau Gregori Czeczko Carlos Hespanha Marinho Junior Ronaldo Kiviatcoski Kozlowski Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats Revista do Colégio Brasileiro de Cirurgiões Hepatectomy Liver Regeneration Fatty acids Fatty acids, Omega-3 |
| title | Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats |
| title_full | Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats |
| title_fullStr | Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats |
| title_full_unstemmed | Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats |
| title_short | Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats |
| title_sort | evaluation of liver regeneration diet supplemented with omega 3 fatty acids experimental study in rats |
| topic | Hepatectomy Liver Regeneration Fatty acids Fatty acids, Omega-3 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000700393&lng=en&tlng=en |
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