Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology
Regulatory T cells (Tregs) are essential for mitigating inflammation. Tregs are found in nearly every tissue and play either beneficial or harmful roles in the host. The availability of various nutrients can either enhance or impair Treg function. Mitochondrial oxidative metabolism plays a major rol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.637960/full |
| _version_ | 1819181645253574656 |
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| author | Julianna Blagih Marc Hennequart Fabio Zani |
| author_facet | Julianna Blagih Marc Hennequart Fabio Zani |
| author_sort | Julianna Blagih |
| collection | DOAJ |
| description | Regulatory T cells (Tregs) are essential for mitigating inflammation. Tregs are found in nearly every tissue and play either beneficial or harmful roles in the host. The availability of various nutrients can either enhance or impair Treg function. Mitochondrial oxidative metabolism plays a major role in supporting Treg differentiation and fitness. While Tregs rely heavily on oxidation of fatty acids to support mitochondrial activity, they have found ways to adapt to different tissue types, such as tumors, to survive in competitive environments. In addition, metabolic by-products from commensal organisms in the gut also have a profound impact on Treg differentiation. In this review, we will focus on the core metabolic pathways engaged in Tregs, especially in the context of tissue nutrient environments, and how they can affect Treg function, stability and differentiation. |
| first_indexed | 2024-12-22T22:33:31Z |
| format | Article |
| id | doaj.art-ec53933c9b7c4987bb87980df10b480e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T22:33:31Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec53933c9b7c4987bb87980df10b480e2022-12-21T18:10:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-04-011210.3389/fimmu.2021.637960637960Tissue Nutrient Environments and Their Effect on Regulatory T Cell BiologyJulianna BlagihMarc HennequartFabio ZaniRegulatory T cells (Tregs) are essential for mitigating inflammation. Tregs are found in nearly every tissue and play either beneficial or harmful roles in the host. The availability of various nutrients can either enhance or impair Treg function. Mitochondrial oxidative metabolism plays a major role in supporting Treg differentiation and fitness. While Tregs rely heavily on oxidation of fatty acids to support mitochondrial activity, they have found ways to adapt to different tissue types, such as tumors, to survive in competitive environments. In addition, metabolic by-products from commensal organisms in the gut also have a profound impact on Treg differentiation. In this review, we will focus on the core metabolic pathways engaged in Tregs, especially in the context of tissue nutrient environments, and how they can affect Treg function, stability and differentiation.https://www.frontiersin.org/articles/10.3389/fimmu.2021.637960/fullregulatory T cellsmetabolismtissuesmetabolic adaptationnutrients |
| spellingShingle | Julianna Blagih Marc Hennequart Fabio Zani Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology Frontiers in Immunology regulatory T cells metabolism tissues metabolic adaptation nutrients |
| title | Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology |
| title_full | Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology |
| title_fullStr | Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology |
| title_full_unstemmed | Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology |
| title_short | Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology |
| title_sort | tissue nutrient environments and their effect on regulatory t cell biology |
| topic | regulatory T cells metabolism tissues metabolic adaptation nutrients |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.637960/full |
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