Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer
Background: Prehabilitation programmes aim to optimise patients before and after cancer treatment including surgery. Previous studies in surgical patients demonstrate that prehabilitation improves pre-operative fitness and overcomes the negative impact of neoadjuvant chemotherapy on fitness. The aim...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/2/118 |
| _version_ | 1797621608062386176 |
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| author | Grigorios Christodoulidis Laura J. Halliday Athina Samara Neel Bhuva Won-Ho Edward Park Krishna Moorthy |
| author_facet | Grigorios Christodoulidis Laura J. Halliday Athina Samara Neel Bhuva Won-Ho Edward Park Krishna Moorthy |
| author_sort | Grigorios Christodoulidis |
| collection | DOAJ |
| description | Background: Prehabilitation programmes aim to optimise patients before and after cancer treatment including surgery. Previous studies in surgical patients demonstrate that prehabilitation improves pre-operative fitness and overcomes the negative impact of neoadjuvant chemotherapy on fitness. The aim of this study was to assess the impact of prehabilitation on the tolerance of neoadjuvant chemotherapy in patients with oesophageal cancer. Methods: Patients with oesophageal or gastroesophageal junction (GOJ) cancer from two oncology centres were retrospectively included in the present comparative cohort study; one provided a multimodal prehabilitation programme and one did not offer any prehabilitation. Tolerance of chemotherapy, defined as completion of the full chemotherapy regime as per protocol, was compared between the two groups. Results: In terms of participants, 92 patients were included in this study, 47 patients in the prehabilitation cohort and 45 in the control cohort. Compared with the control group, the prehabilitation group demonstrated an improved rate of chemotherapy completion (<i>p</i> = 0.029). In multivariate analysis, participation in prehabilitation was significantly associated with an improved rate of chemotherapy completion. Conclusion: The findings of this exploratory study suggest that prehabilitation is associated with better tolerance for chemotherapy. Further research is needed to establish the long-term impact of prehabilitation on oncological outcomes. |
| first_indexed | 2024-03-11T08:58:25Z |
| format | Article |
| id | doaj.art-ec5880ce26f54d7bb577509e45c221c9 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T08:58:25Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-ec5880ce26f54d7bb577509e45c221c92023-11-16T19:57:33ZengMDPI AGCurrent Oncology1198-00521718-77292023-01-013021538154510.3390/curroncol30020118Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal CancerGrigorios Christodoulidis0Laura J. Halliday1Athina Samara2Neel Bhuva3Won-Ho Edward Park4Krishna Moorthy5General Surgery Department, University Hospital of Larisa, 41110 Larisa, GreeceDepartment of Surgery and Cancer, Imperial College London, London W2 1NS, UKGeneral Surgery Department, University Hospital of Larisa, 41110 Larisa, GreeceMount Vernon Cancer Centre, East and North Hertfordshire NHS Trust, Northwood HA6 2RN, UKImperial College Healthcare NHS Trust, London W2 1NS, UKDepartment of Surgery and Cancer, Imperial College London, London W2 1NS, UKBackground: Prehabilitation programmes aim to optimise patients before and after cancer treatment including surgery. Previous studies in surgical patients demonstrate that prehabilitation improves pre-operative fitness and overcomes the negative impact of neoadjuvant chemotherapy on fitness. The aim of this study was to assess the impact of prehabilitation on the tolerance of neoadjuvant chemotherapy in patients with oesophageal cancer. Methods: Patients with oesophageal or gastroesophageal junction (GOJ) cancer from two oncology centres were retrospectively included in the present comparative cohort study; one provided a multimodal prehabilitation programme and one did not offer any prehabilitation. Tolerance of chemotherapy, defined as completion of the full chemotherapy regime as per protocol, was compared between the two groups. Results: In terms of participants, 92 patients were included in this study, 47 patients in the prehabilitation cohort and 45 in the control cohort. Compared with the control group, the prehabilitation group demonstrated an improved rate of chemotherapy completion (<i>p</i> = 0.029). In multivariate analysis, participation in prehabilitation was significantly associated with an improved rate of chemotherapy completion. Conclusion: The findings of this exploratory study suggest that prehabilitation is associated with better tolerance for chemotherapy. Further research is needed to establish the long-term impact of prehabilitation on oncological outcomes.https://www.mdpi.com/1718-7729/30/2/118gastroesophageal junction canceroesophageal cancerprehabilitationchemotherapyradiotherapy |
| spellingShingle | Grigorios Christodoulidis Laura J. Halliday Athina Samara Neel Bhuva Won-Ho Edward Park Krishna Moorthy Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer Current Oncology gastroesophageal junction cancer oesophageal cancer prehabilitation chemotherapy radiotherapy |
| title | Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer |
| title_full | Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer |
| title_fullStr | Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer |
| title_full_unstemmed | Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer |
| title_short | Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer |
| title_sort | personalized prehabilitation improves tolerance to chemotherapy in patients with oesophageal cancer |
| topic | gastroesophageal junction cancer oesophageal cancer prehabilitation chemotherapy radiotherapy |
| url | https://www.mdpi.com/1718-7729/30/2/118 |
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