A novel detection methodology for HER2 protein quantitation in formalin-fixed, paraffin embedded clinical samples using fluorescent nanoparticles: an analytical and clinical validation study

A novel detection methodology for HER2 protein quantitation in formalin-fixed, paraffin embedded clinical samples using fluorescent nanoparticles: an analytical and clinical validation study

Abstract Background Clinical assays for the assessment of the human epidermal growth factor receptor-2 (HER2) status in breast cancer include immunohistochemistry (IHC) and in situ hybridization (ISH), both of which have limitations. Recent studies have suggested that a more quantitative approach to...

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Bibliographic Details
Main Authors: David G. Hicks, Brandon Buscaglia, Hideki Goda, Loralee McMahon, Takako Natori, Bradley Turner, Armen Soukiazian, Hisatake Okada, Yasushi Nakano
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
Breast cancer
HER2
Quantitative protein analysis
Immunohistochemistry
In situ hybridization
Phosphor integrated dot fluorescent nanoparticles
Online Access:http://link.springer.com/article/10.1186/s12885-018-5172-1

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