Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank
Background and objective Obesity and asthma impose a heavy health and economic burden on millions of people around the world. The complex interaction between genetic traits and phenotypes caused the mechanism between obesity and asthma is still vague. This study investigates the relationship among o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-02-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/9/1/e001355.full |
| _version_ | 1827895747401482240 |
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| author | Ta-Chien Chan Chia-Wei Chen Jing-Shiang Hwang Ying-Jhen Huang Yi-Chi Chu Hsin-Chou Yang Hung-Ling Huang Chun-Houh Chen |
| author_facet | Ta-Chien Chan Chia-Wei Chen Jing-Shiang Hwang Ying-Jhen Huang Yi-Chi Chu Hsin-Chou Yang Hung-Ling Huang Chun-Houh Chen |
| author_sort | Ta-Chien Chan |
| collection | DOAJ |
| description | Background and objective Obesity and asthma impose a heavy health and economic burden on millions of people around the world. The complex interaction between genetic traits and phenotypes caused the mechanism between obesity and asthma is still vague. This study investigates the relationship among obesity-related polygenic risk score (PRS), obesity phenotypes and the risk of having asthma.Methods This is a matched case–control study, with 4 controls (8288 non-asthmatic) for each case (2072 asthmatic). Data were obtained from the 2008–2015 Taiwan Biobank Database and linked to the 2000–2016 National Health Insurance Research Database. All participants were ≥30 years old with no history of cancer and had a complete questionnaire, as well as physical examination, genome-wide single nucleotide polymorphisms and clinical diagnosis data. Environmental exposure, PM2.5, was also considered. Multivariate adjusted ORs and 95% CIs were calculated using conditional logistic regression stratified by age and sex. Mediation analysis was also assessed, using a generalised linear model.Results We found that the obese phenotype was associated with significantly increased odds of asthma by approximately 26%. Four obesity-related PRS, including body mass index (OR=1.07 (1.01–1.13)), waist circumference (OR=1.10 (1.04–1.17)), central obesity as defined by waist-to-height ratio (OR=1.09 (1.03–1.15)) and general–central obesity (OR=1.06 (1.00–1.12)), were associated with increased odds of asthma. Additional independent risk factors for asthma included lower educational level, family history of asthma, certain chronic diseases and increased PM2.5 exposure. Obesity-related PRS is an indirect risk factor for asthma, the link being fully mediated by the trait of obesity.Conclusions Obese phenotypes and obesity-related PRS are independent risk factors for having asthma in adults in the Taiwan Biobank. Overall, genetic risk for obesity increases the risk of asthma by affecting the obese phenotype. |
| first_indexed | 2024-03-12T22:26:12Z |
| format | Article |
| id | doaj.art-ec5cc92c24b846e69a0803b991c56bac |
| institution | Directory Open Access Journal |
| issn | 2052-4439 |
| language | English |
| last_indexed | 2024-03-12T22:26:12Z |
| publishDate | 2022-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj.art-ec5cc92c24b846e69a0803b991c56bac2023-07-22T06:00:07ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392022-02-019110.1136/bmjresp-2022-001355Relationship among genetic variants, obesity traits and asthma in the Taiwan BiobankTa-Chien Chan0Chia-Wei Chen1Jing-Shiang Hwang2Ying-Jhen Huang3Yi-Chi Chu4Hsin-Chou Yang5Hung-Ling Huang6Chun-Houh Chen7Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, TaiwanGraduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan2 Institute of Statistical Science, Academia Sinica, Taipei, TaiwanResearch Center for Humanities and Social Sciences, Academia Sinica, Taipei, TaiwanResearch Center for Humanities and Social Sciences, Academia Sinica, Taipei City, TaiwanInstitute of Statistical Science, Academia Sinica, Taipei City, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung City, TaiwanInstitute of Statistical Science, Academia Sinica, Taipei City, TaiwanBackground and objective Obesity and asthma impose a heavy health and economic burden on millions of people around the world. The complex interaction between genetic traits and phenotypes caused the mechanism between obesity and asthma is still vague. This study investigates the relationship among obesity-related polygenic risk score (PRS), obesity phenotypes and the risk of having asthma.Methods This is a matched case–control study, with 4 controls (8288 non-asthmatic) for each case (2072 asthmatic). Data were obtained from the 2008–2015 Taiwan Biobank Database and linked to the 2000–2016 National Health Insurance Research Database. All participants were ≥30 years old with no history of cancer and had a complete questionnaire, as well as physical examination, genome-wide single nucleotide polymorphisms and clinical diagnosis data. Environmental exposure, PM2.5, was also considered. Multivariate adjusted ORs and 95% CIs were calculated using conditional logistic regression stratified by age and sex. Mediation analysis was also assessed, using a generalised linear model.Results We found that the obese phenotype was associated with significantly increased odds of asthma by approximately 26%. Four obesity-related PRS, including body mass index (OR=1.07 (1.01–1.13)), waist circumference (OR=1.10 (1.04–1.17)), central obesity as defined by waist-to-height ratio (OR=1.09 (1.03–1.15)) and general–central obesity (OR=1.06 (1.00–1.12)), were associated with increased odds of asthma. Additional independent risk factors for asthma included lower educational level, family history of asthma, certain chronic diseases and increased PM2.5 exposure. Obesity-related PRS is an indirect risk factor for asthma, the link being fully mediated by the trait of obesity.Conclusions Obese phenotypes and obesity-related PRS are independent risk factors for having asthma in adults in the Taiwan Biobank. Overall, genetic risk for obesity increases the risk of asthma by affecting the obese phenotype.https://bmjopenrespres.bmj.com/content/9/1/e001355.full |
| spellingShingle | Ta-Chien Chan Chia-Wei Chen Jing-Shiang Hwang Ying-Jhen Huang Yi-Chi Chu Hsin-Chou Yang Hung-Ling Huang Chun-Houh Chen Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank BMJ Open Respiratory Research |
| title | Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank |
| title_full | Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank |
| title_fullStr | Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank |
| title_full_unstemmed | Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank |
| title_short | Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank |
| title_sort | relationship among genetic variants obesity traits and asthma in the taiwan biobank |
| url | https://bmjopenrespres.bmj.com/content/9/1/e001355.full |
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