Influence of Microbes on Neutrophil Life and Death
Neutrophils are the most abundant leukocyte in humans and they are among the first white cells recruited to infected tissues. These leukocytes are essential for the innate immune response to bacteria and fungi. Inasmuch as neutrophils produce or contain potent microbicides that can be toxic to the h...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00159/full |
| _version_ | 1819093330947997696 |
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| author | Frank R. DeLeo Scott D. Kobayashi Natalia Malachowa |
| author_facet | Frank R. DeLeo Scott D. Kobayashi Natalia Malachowa |
| author_sort | Frank R. DeLeo |
| collection | DOAJ |
| description | Neutrophils are the most abundant leukocyte in humans and they are among the first white cells recruited to infected tissues. These leukocytes are essential for the innate immune response to bacteria and fungi. Inasmuch as neutrophils produce or contain potent microbicides that can be toxic to the host, neutrophil turnover and homeostasis is a highly regulated process that prevents unintended host tissue damage. Indeed, constitutive neutrophil apoptosis and subsequent removal of these cells by mononuclear phagocytes is a primary means by which neutrophil homeostasis is maintained in healthy individuals. Processes that alter normal neutrophil turnover and removal of effete cells can lead to host tissue damage and disease. The interaction of neutrophils with microbes and molecules produced by microbes often alters neutrophil turnover. The ability of microbes to alter the fate of neutrophils is highly varied, can be microbe-specific, and ranges from prolonging the neutrophil lifespan to causing rapid neutrophil lysis after phagocytosis. Here we provide a brief overview of these processes and their associated impact on innate host defense. |
| first_indexed | 2024-12-21T23:09:48Z |
| format | Article |
| id | doaj.art-ec5d751ed4f64a55a6686934292f88f7 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-21T23:09:48Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-ec5d751ed4f64a55a6686934292f88f72022-12-21T18:47:05ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882017-05-01710.3389/fcimb.2017.00159263145Influence of Microbes on Neutrophil Life and DeathFrank R. DeLeoScott D. KobayashiNatalia MalachowaNeutrophils are the most abundant leukocyte in humans and they are among the first white cells recruited to infected tissues. These leukocytes are essential for the innate immune response to bacteria and fungi. Inasmuch as neutrophils produce or contain potent microbicides that can be toxic to the host, neutrophil turnover and homeostasis is a highly regulated process that prevents unintended host tissue damage. Indeed, constitutive neutrophil apoptosis and subsequent removal of these cells by mononuclear phagocytes is a primary means by which neutrophil homeostasis is maintained in healthy individuals. Processes that alter normal neutrophil turnover and removal of effete cells can lead to host tissue damage and disease. The interaction of neutrophils with microbes and molecules produced by microbes often alters neutrophil turnover. The ability of microbes to alter the fate of neutrophils is highly varied, can be microbe-specific, and ranges from prolonging the neutrophil lifespan to causing rapid neutrophil lysis after phagocytosis. Here we provide a brief overview of these processes and their associated impact on innate host defense.http://journal.frontiersin.org/article/10.3389/fcimb.2017.00159/fullphagocytosishost defenseapoptosisnecroptosisprogrammed cell deathnecrosis |
| spellingShingle | Frank R. DeLeo Scott D. Kobayashi Natalia Malachowa Influence of Microbes on Neutrophil Life and Death Frontiers in Cellular and Infection Microbiology phagocytosis host defense apoptosis necroptosis programmed cell death necrosis |
| title | Influence of Microbes on Neutrophil Life and Death |
| title_full | Influence of Microbes on Neutrophil Life and Death |
| title_fullStr | Influence of Microbes on Neutrophil Life and Death |
| title_full_unstemmed | Influence of Microbes on Neutrophil Life and Death |
| title_short | Influence of Microbes on Neutrophil Life and Death |
| title_sort | influence of microbes on neutrophil life and death |
| topic | phagocytosis host defense apoptosis necroptosis programmed cell death necrosis |
| url | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00159/full |
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