Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts
Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections. In Leishmania-infected cells, expression and /or activatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00146/full |
| _version_ | 1818497969343692800 |
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| author | Peter Epeh Kima Naixin eZhang |
| author_facet | Peter Epeh Kima Naixin eZhang |
| author_sort | Peter Epeh Kima |
| collection | DOAJ |
| description | Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections. In Leishmania-infected cells, expression and /or activation of protein kinases such as the mitogen activated protein kinases (MAPK), kinases in the PI3-kinase signaling pathway and kinases in the NFĸB signaling pathway, are modulated in some manner. Several recent reviews have discussed our current understanding of the roles of these kinase in Leishmania infections. Apart from the kinases in the pathways enumerated above, there are other host cell protein kinases that are activated during the Leishmania infection of mammalian cells whose roles also appear to be significant. This review discusses recent observations on the Abl family of protein kinases and the Protein Kinase regulated by RNA (PKR) in Leishmania infections. |
| first_indexed | 2024-12-10T18:52:04Z |
| format | Article |
| id | doaj.art-ec5dade4d8294c399107635eeeeecfa9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T18:52:04Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec5dade4d8294c399107635eeeeecfa92022-12-22T01:37:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-04-01710.3389/fimmu.2016.00146183110Leishmania infection engages non-receptor protein kinases differentially to persist in infected hostsPeter Epeh Kima0Naixin eZhang1University of FloridaUniversity of FloridaProtein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections. In Leishmania-infected cells, expression and /or activation of protein kinases such as the mitogen activated protein kinases (MAPK), kinases in the PI3-kinase signaling pathway and kinases in the NFĸB signaling pathway, are modulated in some manner. Several recent reviews have discussed our current understanding of the roles of these kinase in Leishmania infections. Apart from the kinases in the pathways enumerated above, there are other host cell protein kinases that are activated during the Leishmania infection of mammalian cells whose roles also appear to be significant. This review discusses recent observations on the Abl family of protein kinases and the Protein Kinase regulated by RNA (PKR) in Leishmania infections.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00146/fullLeishmaniaPhagocytosisProtein KinasesPKRAbl kinase |
| spellingShingle | Peter Epeh Kima Naixin eZhang Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts Frontiers in Immunology Leishmania Phagocytosis Protein Kinases PKR Abl kinase |
| title | Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts |
| title_full | Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts |
| title_fullStr | Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts |
| title_full_unstemmed | Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts |
| title_short | Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts |
| title_sort | leishmania infection engages non receptor protein kinases differentially to persist in infected hosts |
| topic | Leishmania Phagocytosis Protein Kinases PKR Abl kinase |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00146/full |
| work_keys_str_mv | AT peterepehkima leishmaniainfectionengagesnonreceptorproteinkinasesdifferentiallytopersistininfectedhosts AT naixinezhang leishmaniainfectionengagesnonreceptorproteinkinasesdifferentiallytopersistininfectedhosts |