Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study
<p>Abstract</p> <p>Background</p> <p/> <p>To investigate aortic dimensions in women with Turner syndrome (TS) in relation to aortic valve morphology, blood pressure, karyotype, and clinical characteristics.</p> <p>Methods and results</p> <p>...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-03-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Online Access: | http://www.jcmr-online.com/content/12/1/12 |
| _version_ | 1797204499918487552 |
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| author | Hager Alfred Hørlyck Arne Hansen Klavs W Lundorf Erik Andersen Niels H Pedersen Erik M Sørensen Keld E Mortensen Kristian H Hjerrild Britta E Christiansen Jens S Gravholt Claus H |
| author_facet | Hager Alfred Hørlyck Arne Hansen Klavs W Lundorf Erik Andersen Niels H Pedersen Erik M Sørensen Keld E Mortensen Kristian H Hjerrild Britta E Christiansen Jens S Gravholt Claus H |
| author_sort | Hager Alfred |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p/> <p>To investigate aortic dimensions in women with Turner syndrome (TS) in relation to aortic valve morphology, blood pressure, karyotype, and clinical characteristics.</p> <p>Methods and results</p> <p>A cross sectional study of 102 women with TS (mean age 37.7; 18-62 years) examined by cardiovascular magnetic resonance (CMR- successful in 95), echocardiography, and 24-hour ambulatory blood pressure. Aortic diameters were measured by CMR at 8 positions along the thoracic aorta. Twenty-four healthy females were recruited as controls. In TS, aortic dilatation was present at one or more positions in 22 (23%). Aortic diameter in women with TS and bicuspid aortic valve was significantly larger than in TS with tricuspid valves in both the ascending (32.4 ± 6.7 vs. 26.0 ± 4.4 mm; p < 0.001) and descending (21.4 ± 3.5 vs. 18.8 ± 2.4 mm; p < 0.001) aorta. Aortic diameter correlated to age (R = 0.2 - 0.5; p < 0.01), blood pressure (R = 0.4; p < 0.05), a history of coarctation (R = 0.3; p = 0.01) and bicuspid aortic valve (R = 0.2-0.5; p < 0.05). Body surface area only correlated with descending aortic diameter (R = 0.23; p = 0.024).</p> <p>Conclusions</p> <p/> <p>Aortic dilatation was present in 23% of adult TS women, where aortic valve morphology, age and blood pressure were major determinants of the aortic diameter.</p> |
| first_indexed | 2024-04-12T23:50:51Z |
| format | Article |
| id | doaj.art-ec5e00840be447b2a333316b3d58a8ef |
| institution | Directory Open Access Journal |
| issn | 1097-6647 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:36:12Z |
| publishDate | 2010-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-ec5e00840be447b2a333316b3d58a8ef2024-04-16T17:03:48ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2010-03-011211210.1186/1532-429X-12-12Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR studyHager AlfredHørlyck ArneHansen Klavs WLundorf ErikAndersen Niels HPedersen Erik MSørensen Keld EMortensen Kristian HHjerrild Britta EChristiansen Jens SGravholt Claus H<p>Abstract</p> <p>Background</p> <p/> <p>To investigate aortic dimensions in women with Turner syndrome (TS) in relation to aortic valve morphology, blood pressure, karyotype, and clinical characteristics.</p> <p>Methods and results</p> <p>A cross sectional study of 102 women with TS (mean age 37.7; 18-62 years) examined by cardiovascular magnetic resonance (CMR- successful in 95), echocardiography, and 24-hour ambulatory blood pressure. Aortic diameters were measured by CMR at 8 positions along the thoracic aorta. Twenty-four healthy females were recruited as controls. In TS, aortic dilatation was present at one or more positions in 22 (23%). Aortic diameter in women with TS and bicuspid aortic valve was significantly larger than in TS with tricuspid valves in both the ascending (32.4 ± 6.7 vs. 26.0 ± 4.4 mm; p < 0.001) and descending (21.4 ± 3.5 vs. 18.8 ± 2.4 mm; p < 0.001) aorta. Aortic diameter correlated to age (R = 0.2 - 0.5; p < 0.01), blood pressure (R = 0.4; p < 0.05), a history of coarctation (R = 0.3; p = 0.01) and bicuspid aortic valve (R = 0.2-0.5; p < 0.05). Body surface area only correlated with descending aortic diameter (R = 0.23; p = 0.024).</p> <p>Conclusions</p> <p/> <p>Aortic dilatation was present in 23% of adult TS women, where aortic valve morphology, age and blood pressure were major determinants of the aortic diameter.</p>http://www.jcmr-online.com/content/12/1/12 |
| spellingShingle | Hager Alfred Hørlyck Arne Hansen Klavs W Lundorf Erik Andersen Niels H Pedersen Erik M Sørensen Keld E Mortensen Kristian H Hjerrild Britta E Christiansen Jens S Gravholt Claus H Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study Journal of Cardiovascular Magnetic Resonance |
| title | Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study |
| title_full | Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study |
| title_fullStr | Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study |
| title_full_unstemmed | Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study |
| title_short | Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study |
| title_sort | thoracic aortopathy in turner syndrome and the influence of bicuspid aortic valves and blood pressure a cmr study |
| url | http://www.jcmr-online.com/content/12/1/12 |
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