The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications
Subarachnoid hemorrhage (SAH) is an important public health concern with high morbidity and mortality worldwide. SAH induces cell death, blood−brain barrier (BBB) damage, brain edema and oxidative stress. As the most abundant cell type in the central nervous system, astrocytes play an essential role...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008795/full |
| _version_ | 1828385987298852864 |
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| author | Rong Li Min Zhao Di Yao Xiangyue Zhou Cameron Lenahan Ling Wang Yibo Ou Yue He |
| author_facet | Rong Li Min Zhao Di Yao Xiangyue Zhou Cameron Lenahan Ling Wang Yibo Ou Yue He |
| author_sort | Rong Li |
| collection | DOAJ |
| description | Subarachnoid hemorrhage (SAH) is an important public health concern with high morbidity and mortality worldwide. SAH induces cell death, blood−brain barrier (BBB) damage, brain edema and oxidative stress. As the most abundant cell type in the central nervous system, astrocytes play an essential role in brain damage and recovery following SAH. This review describes astrocyte activation and polarization after SAH. Astrocytes mediate BBB disruption, glymphatic–lymphatic system dysfunction, oxidative stress, and cell death after SAH. Furthermore, astrocytes engage in abundant crosstalk with other brain cells, such as endothelial cells, neurons, pericytes, microglia and monocytes, after SAH. In addition, astrocytes also exert protective functions in SAH. Finally, we summarize evidence regarding therapeutic approaches aimed at modulating astrocyte function following SAH, which could provide some new leads for future translational therapy to alleviate damage after SAH. |
| first_indexed | 2024-12-10T05:29:22Z |
| format | Article |
| id | doaj.art-ec5ecc89bfb642ed9198ff97835f3617 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T05:29:22Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec5ecc89bfb642ed9198ff97835f36172022-12-22T02:00:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.10087951008795The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implicationsRong Li0Min Zhao1Di Yao2Xiangyue Zhou3Cameron Lenahan4Ling Wang5Yibo Ou6Yue He7Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Biomedical Sciences, Burrell College of Osteopathic Medicine, Las Cruces, NM, United StatesDepartment of Operating room, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSubarachnoid hemorrhage (SAH) is an important public health concern with high morbidity and mortality worldwide. SAH induces cell death, blood−brain barrier (BBB) damage, brain edema and oxidative stress. As the most abundant cell type in the central nervous system, astrocytes play an essential role in brain damage and recovery following SAH. This review describes astrocyte activation and polarization after SAH. Astrocytes mediate BBB disruption, glymphatic–lymphatic system dysfunction, oxidative stress, and cell death after SAH. Furthermore, astrocytes engage in abundant crosstalk with other brain cells, such as endothelial cells, neurons, pericytes, microglia and monocytes, after SAH. In addition, astrocytes also exert protective functions in SAH. Finally, we summarize evidence regarding therapeutic approaches aimed at modulating astrocyte function following SAH, which could provide some new leads for future translational therapy to alleviate damage after SAH. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008795/fullsubarachnoid hemorrhageastrocyteneurovascular unitastrocyte activationblood-brain barrierglymphatic-meningeal lymphatic system |
| spellingShingle | Rong Li Min Zhao Di Yao Xiangyue Zhou Cameron Lenahan Ling Wang Yibo Ou Yue He The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications Frontiers in Immunology subarachnoid hemorrhage astrocyte neurovascular unit astrocyte activation blood-brain barrier glymphatic-meningeal lymphatic system |
| title | The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications |
| title_full | The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications |
| title_fullStr | The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications |
| title_full_unstemmed | The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications |
| title_short | The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications |
| title_sort | role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications |
| topic | subarachnoid hemorrhage astrocyte neurovascular unit astrocyte activation blood-brain barrier glymphatic-meningeal lymphatic system |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008795/full |
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