New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on mono...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-12-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/2041731417744485 |
| _version_ | 1819048100910596096 |
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| author | Andreas Hoffmann Holger Leonards Nora Tobies Ludwig Pongratz Klaus Kreuels Franziska Kreimendahl Christian Apel Martin Wehner Nadine Nottrodt |
| author_facet | Andreas Hoffmann Holger Leonards Nora Tobies Ludwig Pongratz Klaus Kreuels Franziska Kreimendahl Christian Apel Martin Wehner Nadine Nottrodt |
| author_sort | Andreas Hoffmann |
| collection | DOAJ |
| description | Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization. |
| first_indexed | 2024-12-21T11:10:54Z |
| format | Article |
| id | doaj.art-ec5eec4c3c63405181cd74f49fca55ad |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-21T11:10:54Z |
| publishDate | 2017-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-ec5eec4c3c63405181cd74f49fca55ad2022-12-21T19:06:06ZengSAGE PublishingJournal of Tissue Engineering2041-73142017-12-01810.1177/2041731417744485New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printingAndreas Hoffmann0Holger Leonards1Nora Tobies2Ludwig Pongratz3Klaus Kreuels4Franziska Kreimendahl5Christian Apel6Martin Wehner7Nadine Nottrodt8Fraunhofer Institute for Lasertechnology, Aachen, GermanyFraunhofer Institute for Lasertechnology, Aachen, GermanyFraunhofer Institute for Lasertechnology, Aachen, GermanyFraunhofer Institute for Lasertechnology, Aachen, GermanyFraunhofer Institute for Lasertechnology, Aachen, GermanyDepartment of Biohybrid & Medical Textiles, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, GermanyDepartment of Biohybrid & Medical Textiles, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, GermanyFraunhofer Institute for Lasertechnology, Aachen, GermanyFraunhofer Institute for Lasertechnology, Aachen, GermanyStereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization.https://doi.org/10.1177/2041731417744485 |
| spellingShingle | Andreas Hoffmann Holger Leonards Nora Tobies Ludwig Pongratz Klaus Kreuels Franziska Kreimendahl Christian Apel Martin Wehner Nadine Nottrodt New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing Journal of Tissue Engineering |
| title | New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing |
| title_full | New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing |
| title_fullStr | New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing |
| title_full_unstemmed | New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing |
| title_short | New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing |
| title_sort | new stereolithographic resin providing functional surfaces for biocompatible three dimensional printing |
| url | https://doi.org/10.1177/2041731417744485 |
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