Barrier Perturbation in Porcine Peyer’s Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins

Barrier Perturbation in Porcine Peyer’s Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins

The proinflammatory cytokine tumor necrosis factor (TNF) has been described as one of the main mediators of intestinal inflammatory diseases, affecting the composition of tight junction (TJ) proteins and leading to a disruption of the epithelial barrier. An intact intestinal barrier is mandatory, be...

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Bibliographic Details
Main Authors: Linda Droessler, Valeria Cornelius, Elisa Boehm, Laura Stein, Nora Brunner, Salah Amasheh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Physiology
Subjects:
epithelial barrier
claudins
inflammation
peyer’s patch
tight junction
TNF
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.889552/full

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