IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages

IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages

Syphilis is a multi-stage, sexually transmitted disease caused by the spirochete Treponema pallidum (Tp). Considered broadly, syphilis can be conceptualized as a dualistic process in which spirochete-driven inflammation, the cause of clinical manifestations, coexists to varying extents with bacteria...

Full description

Bibliographic Details
Main Authors:	Kelly L. Hawley, Adriana R. Cruz, Sarah J. Benjamin, Carson J. La Vake, Jorge L. Cervantes, Morgan LeDoyt, Lady G. Ramirez, Daniza Mandich, Mary Fiel-Gan, Melissa J. Caimano, Justin D. Radolf, Juan C. Salazar
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-10-01
Series:	Frontiers in Immunology
Subjects:	Treponema pallidum human macrophage Fcγ receptor phagocytosis phagosomal signaling
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01227/full

Similar Items

Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)
by: Mary R. Ferguson, et al.
Published: (2023-08-01)

The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity
by: Melissa J. Caimano, et al.
Published: (2019-08-01)

Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation
by: Sarah J. Benjamin, et al.
Published: (2021-05-01)

Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.
by: Amit Luthra, et al.
Published: (2020-09-01)

Comparison of optimization methods for human vocal tract resonance properties tuning
by: Radolf V.
Published: (2007-11-01)

CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance.
by: Bikash Sahay, et al.
Published: (2009-12-01)

Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of <italic toggle="yes">Treponema pallidum</italic> subsp. <italic toggle="yes">pallidum</italic>, the Syphilis Spirochete
by: Sanjiv Kumar, et al.
Published: (2018-07-01)

Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission.
by: Star M Dunham-Ems, et al.
Published: (2012-02-01)

Peptide Uptake Is Essential for <italic toggle="yes">Borrelia burgdorferi</italic> Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter
by: Ashley M. Groshong, et al.
Published: (2017-12-01)

Host-specific functional compartmentalization within the oligopeptide transporter during the Borrelia burgdorferi enzootic cycle.
by: Ashley M Groshong, et al.
Published: (2021-01-01)

Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle.
by: Christopher J Pappas, et al.
Published: (2011-07-01)

MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis.
by: Adam C Silver, et al.
Published: (2013-01-01)

Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta.
by: Juan C Salazar, et al.
Published: (2009-05-01)

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by <italic toggle="yes">Borrelia burgdorferi</italic>, the Lyme Disease Spirochete
by: Arianna P. Grove, et al.
Published: (2017-09-01)

BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals
by: André A. Grassmann, et al.
Published: (2023-03-01)

Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments.
by: Adriana R Cruz, et al.
Published: (2012-01-01)

PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi.
by: Ashley M Groshong, et al.
Published: (2021-07-01)

High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny
by: Nicole A. P. Lieberman, et al.
Published: (2022-09-01)

Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis
by: Kristina N. Delgado, et al.
Published: (2022-08-01)

Correction: Role of Acetyl-Phosphate in Activation of the Rrp2-RpoN-RpoS Pathway in.
by: Haijun Xu, et al.
Published: (2010-12-01)

Airflow visualization in a model of human glottis near the self-oscillating vocal folds model
by: Horáček J., et al.
Published: (2011-06-01)

Editorial: Syphilis infection: clinical, epidemiology, basic science, and behavioral research
by: Pingyu Zhou, et al.
Published: (2023-04-01)

Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis.
by: Adriana R Cruz, et al.
Published: (2010-05-01)

A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples
by: Wentao Chen, et al.
Published: (2022-08-01)

Phagosomal TLR signaling upon Borrelia burgdorferi infection
by: Jorge Luis Cervantes, et al.
Published: (2014-05-01)

Influence of PEGylation and RGD loading on the targeting properties of radiolabeled liposomal nanoparticles
by: Rangger C, et al.
Published: (2012-11-01)

Development of a biomarker signature using grating-coupled fluorescence plasmonic microarray for diagnosis of MIS-C
by: Michele Maltz-Matyschsyk, et al.
Published: (2023-03-01)

Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity
by: Nagender Ledala, et al.
Published: (2022-02-01)

Interact : media informed architecture
by: Shea, Justin D. (Justin Daniel)
Published: (2008)

Investigating Why Academically Successful Community College Students Leave College Without a Degree
by: Justin C. Ortagus, et al.
Published: (2021-12-01)

SYPHILITIC INFECTION AND PLACENTAL INSUFFICIENCY
by: N. V. Matyskina, et al.
Published: (2016-10-01)

The leasehold as an alternative ownership structure
by: Lai, Justin(Justin C.)
Published: (2020)

Methods for observational studies using data from massive open online courses
by: Helbert, Justin (Justin C.)
Published: (2016)

Monte Carlo model for designing fluorescent materials in a spectral filter
by: Ging, Justin D. (Justin Daniel), 1976-
Published: (2014)

Implementation of a manufacturing process platform
by: Ging, Justin D. (Justin Daniel), 1976-
Published: (2006)

The safety and efficacy of hip arthroscopy performed using a novel knotless suture anchor
by: Justin Turcotte, et al.
Published: (2021-01-01)

Multifamily site development : Bishop Arts District, Dallas, TX
by: Rice, Justin L. (Justin Lynn)
Published: (2018)

Dopamine Supersensitivity: A Novel Hypothesis of Opioid-Induced Neurobiological Mechanisms Underlying Opioid-Stimulant Co-use and Opioid Relapse
by: Justin C. Strickland, et al.
Published: (2022-04-01)

Adenovirus flow in host cell networks
by: Justin W. Flatt, et al.
Published: (2019-02-01)

Cranial syphilitic gumma
by: Alessandro C. Pasqualotto, et al.
Published: (2020-06-01)