Flipside of the Coin: Iron Deficiency and Colorectal Cancer
Iron deficiency, with or without anemia, is the most frequent hematological manifestation in individuals with cancer, and is especially common in patients with colorectal cancer. Iron is a vital micronutrient that plays an essential role in many biological functions, in the context of which it has b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.635899/full |
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| author | Aysegül Aksan Aysegül Aksan Aysegül Aksan Karima Farrag Karima Farrag Sami Aksan Sami Aksan Oliver Schroeder Oliver Schroeder Jürgen Stein Jürgen Stein Jürgen Stein |
| author_facet | Aysegül Aksan Aysegül Aksan Aysegül Aksan Karima Farrag Karima Farrag Sami Aksan Sami Aksan Oliver Schroeder Oliver Schroeder Jürgen Stein Jürgen Stein Jürgen Stein |
| author_sort | Aysegül Aksan |
| collection | DOAJ |
| description | Iron deficiency, with or without anemia, is the most frequent hematological manifestation in individuals with cancer, and is especially common in patients with colorectal cancer. Iron is a vital micronutrient that plays an essential role in many biological functions, in the context of which it has been found to be intimately linked to cancer biology. To date, however, whereas a large number of studies have comprehensively investigated and reviewed the effects of excess iron on cancer initiation and progression, potential interrelations of iron deficiency with cancer have been largely neglected and are not well-defined. Emerging evidence indicates that reduced iron intake and low systemic iron levels are associated with the pathogenesis of colorectal cancer, suggesting that optimal iron intake must be carefully balanced to avoid both iron deficiency and iron excess. Since iron is vital in the maintenance of immunological functions, insufficient iron availability may enhance oncogenicity by impairing immunosurveillance for neoplastic changes and potentially altering the tumor immune microenvironment. Data from clinical studies support these concepts, showing that iron deficiency is associated with inferior outcomes and reduced response to therapy in patients with colorectal cancer. Here, we elucidate cancer-related effects of iron deficiency, examine preclinical and clinical evidence of its role in tumorigenesis, cancer progression and treatment response. and highlight the importance of adequate iron supplementation to limit these outcomes. |
| first_indexed | 2024-12-16T18:32:37Z |
| format | Article |
| id | doaj.art-ec617fe9708047b6b704445fa148bf9e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T18:32:37Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ec617fe9708047b6b704445fa148bf9e2022-12-21T22:21:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.635899635899Flipside of the Coin: Iron Deficiency and Colorectal CancerAysegül Aksan0Aysegül Aksan1Aysegül Aksan2Karima Farrag3Karima Farrag4Sami Aksan5Sami Aksan6Oliver Schroeder7Oliver Schroeder8Jürgen Stein9Jürgen Stein10Jürgen Stein11Institute of Nutritional Science, Justus-Liebig University, Giessen, GermanyInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, GermanyInterdisziplinäres Crohn Colitis Centrum, Rhein-Main, Frankfurt, GermanyInterdisziplinäres Crohn Colitis Centrum, Rhein-Main, Frankfurt, GermanyDGD Kliniken Sachsenhausen, Frankfurt, GermanyInterdisziplinäres Crohn Colitis Centrum, Rhein-Main, Frankfurt, GermanyDGD Kliniken Sachsenhausen, Frankfurt, GermanyInterdisziplinäres Crohn Colitis Centrum, Rhein-Main, Frankfurt, GermanyDGD Kliniken Sachsenhausen, Frankfurt, GermanyInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, GermanyInterdisziplinäres Crohn Colitis Centrum, Rhein-Main, Frankfurt, GermanyDGD Kliniken Sachsenhausen, Frankfurt, GermanyIron deficiency, with or without anemia, is the most frequent hematological manifestation in individuals with cancer, and is especially common in patients with colorectal cancer. Iron is a vital micronutrient that plays an essential role in many biological functions, in the context of which it has been found to be intimately linked to cancer biology. To date, however, whereas a large number of studies have comprehensively investigated and reviewed the effects of excess iron on cancer initiation and progression, potential interrelations of iron deficiency with cancer have been largely neglected and are not well-defined. Emerging evidence indicates that reduced iron intake and low systemic iron levels are associated with the pathogenesis of colorectal cancer, suggesting that optimal iron intake must be carefully balanced to avoid both iron deficiency and iron excess. Since iron is vital in the maintenance of immunological functions, insufficient iron availability may enhance oncogenicity by impairing immunosurveillance for neoplastic changes and potentially altering the tumor immune microenvironment. Data from clinical studies support these concepts, showing that iron deficiency is associated with inferior outcomes and reduced response to therapy in patients with colorectal cancer. Here, we elucidate cancer-related effects of iron deficiency, examine preclinical and clinical evidence of its role in tumorigenesis, cancer progression and treatment response. and highlight the importance of adequate iron supplementation to limit these outcomes.https://www.frontiersin.org/articles/10.3389/fimmu.2021.635899/fulliron deficiencyiron deficiency anemiacolorectal cancerimmune host defenseintravenous iron therapy |
| spellingShingle | Aysegül Aksan Aysegül Aksan Aysegül Aksan Karima Farrag Karima Farrag Sami Aksan Sami Aksan Oliver Schroeder Oliver Schroeder Jürgen Stein Jürgen Stein Jürgen Stein Flipside of the Coin: Iron Deficiency and Colorectal Cancer Frontiers in Immunology iron deficiency iron deficiency anemia colorectal cancer immune host defense intravenous iron therapy |
| title | Flipside of the Coin: Iron Deficiency and Colorectal Cancer |
| title_full | Flipside of the Coin: Iron Deficiency and Colorectal Cancer |
| title_fullStr | Flipside of the Coin: Iron Deficiency and Colorectal Cancer |
| title_full_unstemmed | Flipside of the Coin: Iron Deficiency and Colorectal Cancer |
| title_short | Flipside of the Coin: Iron Deficiency and Colorectal Cancer |
| title_sort | flipside of the coin iron deficiency and colorectal cancer |
| topic | iron deficiency iron deficiency anemia colorectal cancer immune host defense intravenous iron therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.635899/full |
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