Utility of an improved model of amyloid-beta (Aβ<sub>1-42</sub>) toxicity in <it>Caenorhabditis elegans</it> for drug screening for Alzheimer’s disease

Utility of an improved model of amyloid-beta (Aβ<sub>1-42</sub>) toxicity in <it>Caenorhabditis elegans</it> for drug screening for Alzheimer’s disease

<p>Abstract</p> <p>Background</p> <p>The definitive indicator of Alzheimer’s disease (AD) pathology is the profuse accumulation of amyloid-ß (Aß) within the brain. Various <it>in vitro</it> and cell-based models have been proposed for high throughput drug sc...

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Bibliographic Details
Main Authors: McColl Gawain, Roberts Blaine R, Pukala Tara L, Kenche Vijaya B, Roberts Christine M, Link Christopher D, Ryan Timothy M, Masters Colin L, Barnham Kevin J, Bush Ashley I, Cherny Robert A
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Molecular Neurodegeneration
Subjects:
Amyloid beta peptide
Alzheimer’s disease
Caenorhabditis elegans
8-hydroxyquinoline
PBT2 and drug screen
Online Access:http://www.molecularneurodegeneration.com/content/7/1/57

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