Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy
Therapeutic cancer vaccines have become firmly established as a reliable and proficient form of tumor immunotherapy. They represent a promising approach for substantial advancements in the successful treatment of malignant diseases. One attractive vaccine strategy is using, as the vaccine material,...
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Format: | Article |
Language: | English |
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MDPI AG
2022-10-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/23/20/12263 |
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author | Mladen Korbelik |
author_facet | Mladen Korbelik |
author_sort | Mladen Korbelik |
collection | DOAJ |
description | Therapeutic cancer vaccines have become firmly established as a reliable and proficient form of tumor immunotherapy. They represent a promising approach for substantial advancements in the successful treatment of malignant diseases. One attractive vaccine strategy is using, as the vaccine material, the whole tumor cells treated ex vivo by rapid tumor ablation therapies that instigate stress signaling responses culminating in immunogenic cell death (ICD). One such treatment is photodynamic therapy (PDT). The underlying mechanisms and critical elements responsible for the potency of these vaccines are discussed in this review. Radiotherapy has emerged as a suitable component for the combined therapy protocols with the vaccines. Arguments and prospects for optimizing tumor control using a radiovaccination strategy involving X-ray irradiation plus PDT vaccines are presented, together with the findings supporting its validity. |
first_indexed | 2024-03-09T20:07:16Z |
format | Article |
id | doaj.art-ec641c4d196746dfb66d62fb444f5f64 |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-09T20:07:16Z |
publishDate | 2022-10-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-ec641c4d196746dfb66d62fb444f5f642023-11-24T00:30:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201226310.3390/ijms232012263Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with RadiotherapyMladen Korbelik0BC Cancer, Vancouver, BC V5Z 1L3, CanadaTherapeutic cancer vaccines have become firmly established as a reliable and proficient form of tumor immunotherapy. They represent a promising approach for substantial advancements in the successful treatment of malignant diseases. One attractive vaccine strategy is using, as the vaccine material, the whole tumor cells treated ex vivo by rapid tumor ablation therapies that instigate stress signaling responses culminating in immunogenic cell death (ICD). One such treatment is photodynamic therapy (PDT). The underlying mechanisms and critical elements responsible for the potency of these vaccines are discussed in this review. Radiotherapy has emerged as a suitable component for the combined therapy protocols with the vaccines. Arguments and prospects for optimizing tumor control using a radiovaccination strategy involving X-ray irradiation plus PDT vaccines are presented, together with the findings supporting its validity.https://www.mdpi.com/1422-0067/23/20/12263radiovaccinationcancer vaccinephotodynamic therapy |
spellingShingle | Mladen Korbelik Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy International Journal of Molecular Sciences radiovaccination cancer vaccine photodynamic therapy |
title | Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy |
title_full | Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy |
title_fullStr | Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy |
title_full_unstemmed | Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy |
title_short | Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy |
title_sort | radiovaccination strategy for cancer treatment integrating photodynamic therapy generated vaccines with radiotherapy |
topic | radiovaccination cancer vaccine photodynamic therapy |
url | https://www.mdpi.com/1422-0067/23/20/12263 |
work_keys_str_mv | AT mladenkorbelik radiovaccinationstrategyforcancertreatmentintegratingphotodynamictherapygeneratedvaccineswithradiotherapy |