Pregnancy prevalence and outcomes after optic neuritis in South Korea
Abstract To compare pregnancy rates and complications in women with and without a history of optic neuritis (ON). A nationwide, population-based, retrospective study using data from the Korean National Health Claims from January 2011, to December 2017 was done. ON cohort (ON group) consisting of wom...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38851-x |
| _version_ | 1797769536549683200 |
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| author | Daye Diana Choi Kyung-Ah Kim Kyung-Ah Park Sei Yeul Oh |
| author_facet | Daye Diana Choi Kyung-Ah Kim Kyung-Ah Park Sei Yeul Oh |
| author_sort | Daye Diana Choi |
| collection | DOAJ |
| description | Abstract To compare pregnancy rates and complications in women with and without a history of optic neuritis (ON). A nationwide, population-based, retrospective study using data from the Korean National Health Claims from January 2011, to December 2017 was done. ON cohort (ON group) consisting of women aged 18 to 50 with a history of ON and 1:3 age-matched controls (control group) were compared for pregnancy and delivery rates using logistic regression after adjusting for possible confounders. Pregnancy-ON cohort (pregnancy-ON group), women aged 18 to 55 with a history of ON and pregnancy, and 1:3 age at pregnancy matched controls (pregnancy-control group) were analyzed for pregnancy complications using logistic regression after adjusting for covariates. ON group (n = 2516) showed decreased odds ratio (OR) for pregnancy [Adjusted OR2: 0.716, 95% confidence interval (CI): 0.626–0.820] and delivery (adjusted OR2: 0.647, 95% CI: 0.554–0.756) compared to controls (n = 7548). Pregnancy-ON group (n = 550) showed increased risk of delayed fetal growth (adjusted OR2: 9.867, 95% CI: 1.224–79.564), pre-eclampsia (adjusted OR2: 8.327, 95% CI: 2.911–23.819), preterm delivery (adjusted OR2: 3.914, 95% CI: 2.667–5.742), pregnancy and postpartum infection (adjusted OR1: 1.671, 95% CI: 1.296–2.154), diabetes in pregnancy (adjusted OR2: 1.365, 95% CI: 1.062–1.754) compared to pregnancy-control group (n = 1650). Our population-based cohort study suggests that history of ON is associated with decreased pregnancy and delivery rates. It may be a risk factor for various pregnancy complications. |
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| format | Article |
| id | doaj.art-ec64abea6da24e4cb3a76dcafd26a1bf |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T21:09:31Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-ec64abea6da24e4cb3a76dcafd26a1bf2023-07-30T11:15:48ZengNature PortfolioScientific Reports2045-23222023-07-011311810.1038/s41598-023-38851-xPregnancy prevalence and outcomes after optic neuritis in South KoreaDaye Diana Choi0Kyung-Ah Kim1Kyung-Ah Park2Sei Yeul Oh3Department of Ophthalmology, Kim’s Eye HospitalStatistics and Data Center, Samsung Medical CenterDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract To compare pregnancy rates and complications in women with and without a history of optic neuritis (ON). A nationwide, population-based, retrospective study using data from the Korean National Health Claims from January 2011, to December 2017 was done. ON cohort (ON group) consisting of women aged 18 to 50 with a history of ON and 1:3 age-matched controls (control group) were compared for pregnancy and delivery rates using logistic regression after adjusting for possible confounders. Pregnancy-ON cohort (pregnancy-ON group), women aged 18 to 55 with a history of ON and pregnancy, and 1:3 age at pregnancy matched controls (pregnancy-control group) were analyzed for pregnancy complications using logistic regression after adjusting for covariates. ON group (n = 2516) showed decreased odds ratio (OR) for pregnancy [Adjusted OR2: 0.716, 95% confidence interval (CI): 0.626–0.820] and delivery (adjusted OR2: 0.647, 95% CI: 0.554–0.756) compared to controls (n = 7548). Pregnancy-ON group (n = 550) showed increased risk of delayed fetal growth (adjusted OR2: 9.867, 95% CI: 1.224–79.564), pre-eclampsia (adjusted OR2: 8.327, 95% CI: 2.911–23.819), preterm delivery (adjusted OR2: 3.914, 95% CI: 2.667–5.742), pregnancy and postpartum infection (adjusted OR1: 1.671, 95% CI: 1.296–2.154), diabetes in pregnancy (adjusted OR2: 1.365, 95% CI: 1.062–1.754) compared to pregnancy-control group (n = 1650). Our population-based cohort study suggests that history of ON is associated with decreased pregnancy and delivery rates. It may be a risk factor for various pregnancy complications.https://doi.org/10.1038/s41598-023-38851-x |
| spellingShingle | Daye Diana Choi Kyung-Ah Kim Kyung-Ah Park Sei Yeul Oh Pregnancy prevalence and outcomes after optic neuritis in South Korea Scientific Reports |
| title | Pregnancy prevalence and outcomes after optic neuritis in South Korea |
| title_full | Pregnancy prevalence and outcomes after optic neuritis in South Korea |
| title_fullStr | Pregnancy prevalence and outcomes after optic neuritis in South Korea |
| title_full_unstemmed | Pregnancy prevalence and outcomes after optic neuritis in South Korea |
| title_short | Pregnancy prevalence and outcomes after optic neuritis in South Korea |
| title_sort | pregnancy prevalence and outcomes after optic neuritis in south korea |
| url | https://doi.org/10.1038/s41598-023-38851-x |
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