Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case)
Aim. To demonstrate an interesting clinical case of treating a patient with intradermal melanoma metastases.Materials and methods. A patient with intradermal melanoma metastases was given a combined treatment including photodynamic therapy (PDT) and immunotherapy (intradermal administration of an im...
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2020-06-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/2224 |
| _version_ | 1826568739935485952 |
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| author | O. N. Ganusevich T. N. Nesterovich I. V. Fedorkevich A. S. Yakovenko |
| author_facet | O. N. Ganusevich T. N. Nesterovich I. V. Fedorkevich A. S. Yakovenko |
| author_sort | O. N. Ganusevich |
| collection | DOAJ |
| description | Aim. To demonstrate an interesting clinical case of treating a patient with intradermal melanoma metastases.Materials and methods. A patient with intradermal melanoma metastases was given a combined treatment including photodynamic therapy (PDT) and immunotherapy (intradermal administration of an immunological preparation into metastatic foci).Results. A clinical case of a patient with a locoregional recurrence of skin melanoma (SM) of the left lower leg was described. Given the prevalence of the pathological substrate and the presence of concomitant pathologies, two treatment methods were selected – PDT and intradermal administration of interferon into metastatic foci. These methods provided both the local and systemic effect. As a result, the stabilisation of the tumour process was achieved.Conclusion. Combined treatment of locoregional recurrences of skin melanoma using PDT and intrametastatic injections of immunopreparations can be used as an alternative to surgical intervention in somatically weakened patients with a large area of intradermal metastases, which will allow the tumour process to be stabilised. In cases where the area of locoregional intradermal recurrences in somatically compensated patients does not permit surgical treatment, the proposed technique may be the only possible treatment method. |
| first_indexed | 2024-03-07T21:47:58Z |
| format | Article |
| id | doaj.art-ec664069e37c4798ae84d1293136b0f9 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2025-03-14T11:28:14Z |
| publishDate | 2020-06-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-ec664069e37c4798ae84d1293136b0f92025-03-02T10:05:35ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442020-06-0127310511210.25207/1608-6228-2020-27-3-105-1121190Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case)O. N. Ganusevich0T. N. Nesterovich1I. V. Fedorkevich2A. S. Yakovenko3Gomel Regional Clinical Oncology DispensaryGomel State Medical UniversityGomel Regional Clinical Oncology DispensaryGomel Regional Clinical Oncology DispensaryAim. To demonstrate an interesting clinical case of treating a patient with intradermal melanoma metastases.Materials and methods. A patient with intradermal melanoma metastases was given a combined treatment including photodynamic therapy (PDT) and immunotherapy (intradermal administration of an immunological preparation into metastatic foci).Results. A clinical case of a patient with a locoregional recurrence of skin melanoma (SM) of the left lower leg was described. Given the prevalence of the pathological substrate and the presence of concomitant pathologies, two treatment methods were selected – PDT and intradermal administration of interferon into metastatic foci. These methods provided both the local and systemic effect. As a result, the stabilisation of the tumour process was achieved.Conclusion. Combined treatment of locoregional recurrences of skin melanoma using PDT and intrametastatic injections of immunopreparations can be used as an alternative to surgical intervention in somatically weakened patients with a large area of intradermal metastases, which will allow the tumour process to be stabilised. In cases where the area of locoregional intradermal recurrences in somatically compensated patients does not permit surgical treatment, the proposed technique may be the only possible treatment method.https://ksma.elpub.ru/jour/article/view/2224melanomaintradermal metastasesphotodynamic therapyimmunotherapy |
| spellingShingle | O. N. Ganusevich T. N. Nesterovich I. V. Fedorkevich A. S. Yakovenko Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case) Кубанский научный медицинский вестник melanoma intradermal metastases photodynamic therapy immunotherapy |
| title | Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case) |
| title_full | Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case) |
| title_fullStr | Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case) |
| title_full_unstemmed | Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case) |
| title_short | Treatment of Locoregional Recurrences of Skin Melanoma (a Clinical Case) |
| title_sort | treatment of locoregional recurrences of skin melanoma a clinical case |
| topic | melanoma intradermal metastases photodynamic therapy immunotherapy |
| url | https://ksma.elpub.ru/jour/article/view/2224 |
| work_keys_str_mv | AT onganusevich treatmentoflocoregionalrecurrencesofskinmelanomaaclinicalcase AT tnnesterovich treatmentoflocoregionalrecurrencesofskinmelanomaaclinicalcase AT ivfedorkevich treatmentoflocoregionalrecurrencesofskinmelanomaaclinicalcase AT asyakovenko treatmentoflocoregionalrecurrencesofskinmelanomaaclinicalcase |