Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria
Due to their ability to eliminate antimicrobial resistant (AMR) bacteria and to modulate the immune response, host defence peptides (HDPs) hold great promise for the clinical treatment of bacterial infections. Whereas monotherapy with HDPs is not likely to become an effective first-line treatment, c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/10/1518 |
| _version_ | 1828715156408893440 |
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| author | Patrick R. Lennard Pieter S. Hiemstra Peter H. Nibbering |
| author_facet | Patrick R. Lennard Pieter S. Hiemstra Peter H. Nibbering |
| author_sort | Patrick R. Lennard |
| collection | DOAJ |
| description | Due to their ability to eliminate antimicrobial resistant (AMR) bacteria and to modulate the immune response, host defence peptides (HDPs) hold great promise for the clinical treatment of bacterial infections. Whereas monotherapy with HDPs is not likely to become an effective first-line treatment, combinations of such peptides with antibiotics can potentially provide a path to future therapies for AMR infections. Therefore, we critically reviewed the recent literature regarding the antibacterial activity of combinations of HDPs and antibiotics against AMR bacteria and the approaches taken in these studies. Of the 86 studies compiled, 56 featured a formal assessment of synergy between agents. Of the combinations assessed, synergistic and additive interactions between HDPs and antibiotics amounted to 84.9% of the records, while indifferent and antagonistic interactions accounted for 15.1%. Penicillin, aminoglycoside, fluoro/quinolone, and glycopeptide antibiotic classes were the most frequently documented as interacting with HDPs, and <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Enterococcus faecium</i> were the most reported bacterial species. Few studies formally evaluated the effects of combinations of HDPs and antibiotics on bacteria, and even fewer assessed such combinations against bacteria within biofilms, in animal models, or in advanced tissue infection models. Despite the biases of the current literature, the studies suggest that effective combinations of HDPs and antibiotics hold promise for the future treatment of infections caused by AMR bacteria. |
| first_indexed | 2024-03-10T21:29:54Z |
| format | Article |
| id | doaj.art-ec6751889ac34d43b54f06de88c8bbf8 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T21:29:54Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ec6751889ac34d43b54f06de88c8bbf82023-11-19T15:26:37ZengMDPI AGAntibiotics2079-63822023-10-011210151810.3390/antibiotics12101518Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant BacteriaPatrick R. Lennard0Pieter S. Hiemstra1Peter H. Nibbering2Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UKPulmoScience Lab, Department of Pulmonology, Leiden University Medical Centre, Leiden 2333, The NetherlandsDepartment of Infectious Diseases, Leiden University Medical Centre, Leiden 2333, The NetherlandsDue to their ability to eliminate antimicrobial resistant (AMR) bacteria and to modulate the immune response, host defence peptides (HDPs) hold great promise for the clinical treatment of bacterial infections. Whereas monotherapy with HDPs is not likely to become an effective first-line treatment, combinations of such peptides with antibiotics can potentially provide a path to future therapies for AMR infections. Therefore, we critically reviewed the recent literature regarding the antibacterial activity of combinations of HDPs and antibiotics against AMR bacteria and the approaches taken in these studies. Of the 86 studies compiled, 56 featured a formal assessment of synergy between agents. Of the combinations assessed, synergistic and additive interactions between HDPs and antibiotics amounted to 84.9% of the records, while indifferent and antagonistic interactions accounted for 15.1%. Penicillin, aminoglycoside, fluoro/quinolone, and glycopeptide antibiotic classes were the most frequently documented as interacting with HDPs, and <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Enterococcus faecium</i> were the most reported bacterial species. Few studies formally evaluated the effects of combinations of HDPs and antibiotics on bacteria, and even fewer assessed such combinations against bacteria within biofilms, in animal models, or in advanced tissue infection models. Despite the biases of the current literature, the studies suggest that effective combinations of HDPs and antibiotics hold promise for the future treatment of infections caused by AMR bacteria.https://www.mdpi.com/2079-6382/12/10/1518host defence peptideantimicrobial peptideantibioticssynergismantimicrobial resistance |
| spellingShingle | Patrick R. Lennard Pieter S. Hiemstra Peter H. Nibbering Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria Antibiotics host defence peptide antimicrobial peptide antibiotics synergism antimicrobial resistance |
| title | Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria |
| title_full | Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria |
| title_fullStr | Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria |
| title_full_unstemmed | Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria |
| title_short | Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria |
| title_sort | complementary activities of host defence peptides and antibiotics in combating antimicrobial resistant bacteria |
| topic | host defence peptide antimicrobial peptide antibiotics synergism antimicrobial resistance |
| url | https://www.mdpi.com/2079-6382/12/10/1518 |
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